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Table 1 Main difference between the two isoforms MAO-A and MAO-B

From: Molecular docking studies of coumarin hybrids as potential acetylcholinesterase, butyrylcholinesterase, monoamine oxidase A/B and β-amyloid inhibitors for Alzheimer’s disease

MAO-A MAO-B
It preferentially oxidizes nor-epinephrine and serotonin Preferentially deaminates β-phenylethylamine and benzyl-amine [65, 66]
It is selectively inhibited by clorgyline Selectively inhibited by l-deprenyl [65, 66]
Both the MAO isoforms have a different tissue distribution. Occurs in cathecholaminergic neurons as well as glia MAO-B is predominant in the human brain, and is compartmentalized into different cell types. It occurs mainly in glial cells and serotoninergic neurons [67, 68]
MAO-A inhibitors have been used mostly in the treatment of mental disorders, in particular depression and anxiety [80, 81] Used in the treatment of Parkinson’s disease and perhaps, Alzheimer’s disease [70, 82]