Table 2 Antimicrobial activity (MIC = μM/ml) of newly synthesized compounds
From: Synthesis, SAR and in vitro therapeutic potentials of thiazolidine-2,4-diones
Compound | Minimum inhibitory concentration (μΜ/ml) | ||||||
|---|---|---|---|---|---|---|---|
Bacteria | Fungi | ||||||
B. subtilis | S. aureus | K. pneumonia | E. coli | S. typhi | A. niger | C. albicans | |
1 | 9.90 | 4.90 | 9.90 | 4.90 | 4.90 | 4.90 | 4.90 |
2 | 10.40 | 5.21 | 5.21 | 5.21 | 20.80 | 5.21 | 5.21 |
3 | 4.50 | 4.50 | 9.12 | 9.12 | 4.50 | 4.50 | 4.50 |
4 | 9.90 | 4.99 | 9.90 | 4.50 | 4.99 | 4.99 | 4.99 |
5 | 5.65 | 5.65 | 11.30 | 11.30 | 5.65 | 5.65 | 5.65 |
6 | 5.00 | 5.00 | 10.06 | 4.99 | 5.00 | 10.06 | 20.10 |
7 | 9.90 | 4.99 | 4.99 | 4.99 | 4.99 | 9.90 | 4.99 |
8 | 4.50 | 4.50 | 4.50 | 5.00 | 4.50 | 4.50 | 4.50 |
9 | 8.79 | 4.30 | 8.79 | 8.79 | 4.30 | 4.30 | 4.30 |
10 | 4.20 | 4.20 | 4.20 | 8.40 | 4.20 | 4.20 | 4.20 |
11 | 9.40 | 4.70 | 4.70 | 4.70 | 4.70 | 4.70 | 4.70 |
12 | 10.60 | 10.60 | 10.60 | 5.31 | 5.31 | 5.31 | 5.31 |
13 | 10.40 | 5.21 | 10.40 | 5.21 | 5.21 | 2.60 | 5.21 |
14 | 5.21 | 5.21 | 10.60 | 10.40 | 5.21 | 2.60 | 5.21 |
15 | 5.31 | 5.31 | 2.60 | 5.31 | 5.31 | 5.31 | 5.31 |
16 | 5.31 | 5.31 | 10.60 | 5.31 | 5.31 | 5.31 | 5.31 |
17 | 11.30 | 5.65 | 11.30 | 5.65 | 5.65 | 5.65 | 5.65 |
18 | 4.90 | 4.90 | 9.90 | 4.90 | 4.90 | 4.90 | 4.90 |
19 | 4.70 | 4.70 | 9.40 | 4.70 | 4.70 | 4.70 | 4.70 |
20 | 5.40 | 5.40 | 10.80 | 5.40 | 5.40 | 5.40 | 5.40 |
21 | 5.30 | 5.30 | 10.70 | 5.30 | 5.30 | 5.30 | 5.30 |
Cefadroxil | 3.40 | 1.71 | 3.40 | 1.71 | 1.71 | – | – |
Fluconazole | – | – | – | – | – | 4.08 | 4.08 |