Synthesis, SAR and in vitro therapeutic potentials of thiazolidine-2,4-diones

BMC Chemistry

Table 1 The physicochemical properties of newly synthesized derivatives (1–21)

Compound	M. formula	M. weight	m.pt. (°C)	R_f value	% yield
1	C₁₀H₆N₂O₄S	250.23	178–180	0.73	98.00
2	C₁₀H₆ClNO₂S	239.68	150–153	0.51	98.17
3	C₁₀H₅Cl₂NO₂S	274.12	167–170	0.58	95.57
4	C₁₀H₆N₂O₄S	250.23	128–130	0.66	98.73
5	C₁₀H₇NO₃S	221.23	160–165	0.65	97.56
6	C₁₂H₁₂N₂O₂S	248.3	147–150	0.63	79.92
7	C₁₀H₆N₂O₄S	250.23	110–113	0.72	95.73
8	C₁₄H₁₆N₂O₂S	276.35	158–160	0.61	67.93
9	C₁₀H₆BrNO₂S	284.13	150–152	0.63	96.52
10	C₁₃H₁₃NO₅S	295.31	210–213	0.61	98.18
11	C₁₂H₁₁NO₄S	265.29	158–160	0.72	94.33
12	C₁₁H₉NO₃S	235.26	187–190	0.71	98.00
13	C₁₀H₆ClNO₂S	239.68	133–135	0.66	78.89
14	C₁₀H₆ClNO₂S	239.65	137–140	0.76	88.91
15	C₁₁H₉NO₃S	235.26	147–150	0.63	77.89
16	C₁₁H₉NO₃S	235.26	217–220	0.41	95.78
17	C₁₀H₇NO₃S	221.23	227–230	0.46	89.45
18	C₁₁H₉NO₄S	251.26	240–243	0.33	97.97
19	C₁₂H₁₁NO₄S	265.29	220–223	0.57	81.47
20	C₁₂H₉NO₂S	231.27	130–133	0.43	90.20
21	C₁₁H₇NO₃S	233.24	147–150	0.91	96.78

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