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Table 1 The physicochemical properties of newly synthesized derivatives (121)

From: Synthesis, SAR and in vitro therapeutic potentials of thiazolidine-2,4-diones

Compound M. formula M. weight m.pt. (°C) Rf value % yield
1 C10H6N2O4S 250.23 178–180 0.73 98.00
2 C10H6ClNO2S 239.68 150–153 0.51 98.17
3 C10H5Cl2NO2S 274.12 167–170 0.58 95.57
4 C10H6N2O4S 250.23 128–130 0.66 98.73
5 C10H7NO3S 221.23 160–165 0.65 97.56
6 C12H12N2O2S 248.3 147–150 0.63 79.92
7 C10H6N2O4S 250.23 110–113 0.72 95.73
8 C14H16N2O2S 276.35 158–160 0.61 67.93
9 C10H6BrNO2S 284.13 150–152 0.63 96.52
10 C13H13NO5S 295.31 210–213 0.61 98.18
11 C12H11NO4S 265.29 158–160 0.72 94.33
12 C11H9NO3S 235.26 187–190 0.71 98.00
13 C10H6ClNO2S 239.68 133–135 0.66 78.89
14 C10H6ClNO2S 239.65 137–140 0.76 88.91
15 C11H9NO3S 235.26 147–150 0.63 77.89
16 C11H9NO3S 235.26 217–220 0.41 95.78
17 C10H7NO3S 221.23 227–230 0.46 89.45
18 C11H9NO4S 251.26 240–243 0.33 97.97
19 C12H11NO4S 265.29 220–223 0.57 81.47
20 C12H9NO2S 231.27 130–133 0.43 90.20
21 C11H7NO3S 233.24 147–150 0.91 96.78
  1. TLC mobile phase-n-hexane:ethylacetate