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Table 3 Multicomponent synthesis of isoxazole derivatives

From: Green multicomponent synthesis, antimicrobial and antioxidant evaluation of novel 5-amino-isoxazole-4-carbonitriles

Entry

Conditions

Catalyst

Time (min)

Yield (%)

References

1

EtOH, reflux

DABCOa

1.5–15

65–85

[13]

2

CH3CN, rt

3600–9000

70–93

[14]

3

aq. EtOH, hν

CH3CO2Na

5–10

61–89

[15]

4

H2O, rt

KPb

30–150

85–96

[16]

5

H2O, rt

Boric acid

50–1440

82–95

[17]

  1. a1,4-Diazabicyclo[2]octane
  2. bPotassium phthalimide