An integrated approach towards the development of novel antifungal agents containing thiadiazole: synthesis and a combined similarity search, homology modelling, molecular dynamics and molecular docking study

Table 2 Percentage inhibition of compounds against test fungi (%)

Compounds	FOL		MF		AS
	Doses (µg/ml)		Doses (µg/ml)		Doses (µg/ml)
	500	1000	500	500	1000	500
C−	–	–	–	–	–	–
3	40	49	57	73	50	59
4	59	71	45	57	37	53
6a	53	68	54	64	43	53
6b	44	63	67	80	42	58
6c	55	71	65	73	43	59
6d	45	61	58	72	37	47
6e	44	61	49	69	57	69
6f	56	69	58	75	39	61
6g	62	74	64	73	54	68
6h	61	77	46	61	38	48
6i	41	56	49	70	40	50
6j	53	75	61	72	45	61
6k	50	67	80	82	45	61
6l	53	70	46	63	29	43
6m	55	75	45	66	44	58
6n	57	71	51	73	48	64
7a	54	74	57	72	45	56
7b	54	72	67	80	43	55
7c	63	78	61	71	41	56
7d	46	59	60	71	43	50
7e	54	69	43	67	44	65
7f	53	66	50	66	32	44
7g	49	64	48	85	49	64
7h	59	73	47	69	31	43
7i	50	63	59	71	36	44
7j	45	66	47	81	40	62
7k	48	64	50	67	36	46
7l	54	66	37	69	40	51
7m	54	67	41	64	27	46
7n	55	70	69	75	50	73
C+	100	100	100	100	100	100

(−), no percentage inhibition; FOL, Fusarium oxysporum f. sp. lycopersici; MF, Monilia fructigena; AS, Alternaria solani

ISSN: 2661-801X