Skip to main content

Table 1 Inhibition zones of compounds against plant pathogens

From: An integrated approach towards the development of novel antifungal agents containing thiadiazole: synthesis and a combined similarity search, homology modelling, molecular dynamics and molecular docking study

Compounds

Mean zone of inhibition (mm)a

Fusarium oxysporum f. sp. lycopersici

Monilia fructigena

Alternaria solani

Doses (µg/ml)

Doses (µg/ml)

Doses (µg/ml)

500

1000

500

1000

500

1000

C−

0 ± 0.00

0 ± 0.00

0 ± 0.00

3

10.12 ± 0.91

12.35 ± 0.52

14.16 ± 0.80

18.19 ± 0.86

12.45 ± 0.49

14.81 ± 0.56

4

14.67 ± 0.93

17.81 ± 1.02

11.19 ± 0.59

14.25 ± 0.54

9.35 ± 0.33

13.18 ± 1.25

6a

13.19 ± 0.67

17.08 ± 0.72

13.40 ± 0.23

15.88 ± 0.41

10.76 ± 0.29

13.31 ± 0.84

6b

10.92 ± 0.22

15.68 ± 0.97

16.87 ± 0.32

20.08 ± 0.40

10.40 ± 0.42

14.61 ± 0.37

6c

13.83 ± 0.30

17.82 ± 0.09

16.31 ± 1.36

18.34 ± 0.34

10.70 ± 0.83

14.73 ± 0.94

6d

11.27 ± 0.53

15.33 ± 0.36

14.44 ± 3.38

18.09 ± 1.67

9.18 ± 0.59

11.73 ± 0.34

6e

11.11 ± 0.61

15.14 ± 1.02

12.20 ± 0.74

17.17 ± 1.20

14.27 ± 3.18

17.15 ± 1.68

6f

13.95 ± 0.58

17.30 ± 0.73

14.45 ± 0.60

18.65 ± 0.51

9.74 ± 0.63

15.21 ± 1.15

6g

15.51 ± 0.28

18.53 ± 0.39

16.08 ± 0.19

18.30 ± 0.16

13.44 ± 1.00

16.92 ± 0.12

6h

15.25 ± 0.30

19.14 ± 0.40

11.59 ± 0.58

15.13 ± 1.68

9.57 ± 0.30

11.94 ± 0.35

6i

10.33 ± 1.29

13.88 ± 1.08

12.37 ± 3.66

17.40 ± 1.21

9.96 ± 0.33

12.56 ± 0.34

6j

13.31 ± 0.87

18.80 ± 0.74

15.28 ± 0.85

17.93 ± 0.50

11.37 ± 1.38

15.27 ± 1.29

6k

12.47 ± 0.78

16.67 ± 0.94

19.95 ± 1.49

20.52 ± 1.24

11.16 ± 0.20

15.19 ± 0.90

6l

13.25 ± 1.59

17.52 ± 0.45

11.44 ± 0.31

15.84 ± 0.39

7.31 ± 0.03

10.73 ± 0.08

6m

13.69 ± 1.28

18.69 ± 1.28

11.37 ± 1.22

16.59 ± 1.15

11.10 ± 0.36

14.61 ± 0.56

6n

14.36 ± 0.44

17.76 ± 0.16

12.71 ± 0.52

18.23 ± 0.58

12.05 ± 0.29

15.96 ± 0.16

7a

13.48 ± 1.07

18.51 ± 1.71

14.31 ± 0.33

17.99 ± 0.29

11.29 ± 0.25

14.01 ± 1.11

7b

13.40 ± 1.39

17.98 ± 0.58

16.83 ± 1.89

20.04 ± 0.95

10.67 ± 0.48

13.73 ± 0.89

7c

15.71 ± 1.25

19.51 ± 0.78

15.34 ± 0.27

17.64 ± 0.38

10.18 ± 0.59

14.10 ± 1.64

7d

11.39 ± 0.04

14.80 ± 0.45

14.95 ± 0.32

17.72 ± 0.23

10.69 ± 0.64

12.57 ± 0.63

7e

13.48 ± 0.30

17.33 ± 0.52

10.73 ± 0.51

16.83 ± 0.36

10.90 ± 0.32

16.24 ± 0.26

7f

13.31 ± 0.31

16.56 ± 0.61

12.42 ± 1.43

16.54 ± 0.79

8.02 ± 0.60

10.88 ± 0.37

7g

12.22 ± 0.29

15.91 ± 0.63

11.90 ± 0.71

21.23 ± 0.97

12.19 ± 0.52

15.88 ± 1.13

7h

14.68 ± 0.94

18.13 ± 0.46

11.65 ± 0.89

17.34 ± 0.78

7.72 ± 0.44

10.87 ± 0.44

7i

12.57 ± 0.41

15.81 ± 0.51

14.84 ± 0.23

17.67 ± 0.11

9.04 ± 0.46

11.01 ± 0.55

7j

11.19 ± 0.95

16.40 ± 0.55

11.77 ± 0.86

20.16 ± 1.81

9.94 ± 0.26

15.38 ± 0.05

7k

11.97 ± 1.30

15.90 ± 1.00

12.61 ± 2.09

16.66 ± 0.94

8.92 ± 1.22

11.38 ± 0.49

7l

13.55 ± 0.37

16.38 ± 0.31

9.36 ± 0.92

17.36 ± 0.24

9.90 ± 0.21

12.71 ± 0.79

7m

13.59 ± 1.88

16.82 ± 0.14

10.17 ± 1.15

16.06 ± 1.46

6.86 ± 0.63

11.54 ± 0.41

7n

13.65 ± 0.69

17.54 ± 0.52

17.31 ± 1.02

18.74 ± 0.31

12.50 ± 0.45

18.19 ± 0.84

C+

25.00 ± 1.32

25.00 ± 0.98

25.00 ± 0.53

  1. Inhibition zone (IZ) ± standard deviation (SD); C+, positive control (Thiram); C−, negative control (DMSO)
  2. aMean of three assays