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Table 1 Inhibition zones of compounds against plant pathogens

From: An integrated approach towards the development of novel antifungal agents containing thiadiazole: synthesis and a combined similarity search, homology modelling, molecular dynamics and molecular docking study

Compounds Mean zone of inhibition (mm)a
Fusarium oxysporum f. sp. lycopersici Monilia fructigena Alternaria solani
Doses (µg/ml) Doses (µg/ml) Doses (µg/ml)
500 1000 500 1000 500 1000
C− 0 ± 0.00 0 ± 0.00 0 ± 0.00
3 10.12 ± 0.91 12.35 ± 0.52 14.16 ± 0.80 18.19 ± 0.86 12.45 ± 0.49 14.81 ± 0.56
4 14.67 ± 0.93 17.81 ± 1.02 11.19 ± 0.59 14.25 ± 0.54 9.35 ± 0.33 13.18 ± 1.25
6a 13.19 ± 0.67 17.08 ± 0.72 13.40 ± 0.23 15.88 ± 0.41 10.76 ± 0.29 13.31 ± 0.84
6b 10.92 ± 0.22 15.68 ± 0.97 16.87 ± 0.32 20.08 ± 0.40 10.40 ± 0.42 14.61 ± 0.37
6c 13.83 ± 0.30 17.82 ± 0.09 16.31 ± 1.36 18.34 ± 0.34 10.70 ± 0.83 14.73 ± 0.94
6d 11.27 ± 0.53 15.33 ± 0.36 14.44 ± 3.38 18.09 ± 1.67 9.18 ± 0.59 11.73 ± 0.34
6e 11.11 ± 0.61 15.14 ± 1.02 12.20 ± 0.74 17.17 ± 1.20 14.27 ± 3.18 17.15 ± 1.68
6f 13.95 ± 0.58 17.30 ± 0.73 14.45 ± 0.60 18.65 ± 0.51 9.74 ± 0.63 15.21 ± 1.15
6g 15.51 ± 0.28 18.53 ± 0.39 16.08 ± 0.19 18.30 ± 0.16 13.44 ± 1.00 16.92 ± 0.12
6h 15.25 ± 0.30 19.14 ± 0.40 11.59 ± 0.58 15.13 ± 1.68 9.57 ± 0.30 11.94 ± 0.35
6i 10.33 ± 1.29 13.88 ± 1.08 12.37 ± 3.66 17.40 ± 1.21 9.96 ± 0.33 12.56 ± 0.34
6j 13.31 ± 0.87 18.80 ± 0.74 15.28 ± 0.85 17.93 ± 0.50 11.37 ± 1.38 15.27 ± 1.29
6k 12.47 ± 0.78 16.67 ± 0.94 19.95 ± 1.49 20.52 ± 1.24 11.16 ± 0.20 15.19 ± 0.90
6l 13.25 ± 1.59 17.52 ± 0.45 11.44 ± 0.31 15.84 ± 0.39 7.31 ± 0.03 10.73 ± 0.08
6m 13.69 ± 1.28 18.69 ± 1.28 11.37 ± 1.22 16.59 ± 1.15 11.10 ± 0.36 14.61 ± 0.56
6n 14.36 ± 0.44 17.76 ± 0.16 12.71 ± 0.52 18.23 ± 0.58 12.05 ± 0.29 15.96 ± 0.16
7a 13.48 ± 1.07 18.51 ± 1.71 14.31 ± 0.33 17.99 ± 0.29 11.29 ± 0.25 14.01 ± 1.11
7b 13.40 ± 1.39 17.98 ± 0.58 16.83 ± 1.89 20.04 ± 0.95 10.67 ± 0.48 13.73 ± 0.89
7c 15.71 ± 1.25 19.51 ± 0.78 15.34 ± 0.27 17.64 ± 0.38 10.18 ± 0.59 14.10 ± 1.64
7d 11.39 ± 0.04 14.80 ± 0.45 14.95 ± 0.32 17.72 ± 0.23 10.69 ± 0.64 12.57 ± 0.63
7e 13.48 ± 0.30 17.33 ± 0.52 10.73 ± 0.51 16.83 ± 0.36 10.90 ± 0.32 16.24 ± 0.26
7f 13.31 ± 0.31 16.56 ± 0.61 12.42 ± 1.43 16.54 ± 0.79 8.02 ± 0.60 10.88 ± 0.37
7g 12.22 ± 0.29 15.91 ± 0.63 11.90 ± 0.71 21.23 ± 0.97 12.19 ± 0.52 15.88 ± 1.13
7h 14.68 ± 0.94 18.13 ± 0.46 11.65 ± 0.89 17.34 ± 0.78 7.72 ± 0.44 10.87 ± 0.44
7i 12.57 ± 0.41 15.81 ± 0.51 14.84 ± 0.23 17.67 ± 0.11 9.04 ± 0.46 11.01 ± 0.55
7j 11.19 ± 0.95 16.40 ± 0.55 11.77 ± 0.86 20.16 ± 1.81 9.94 ± 0.26 15.38 ± 0.05
7k 11.97 ± 1.30 15.90 ± 1.00 12.61 ± 2.09 16.66 ± 0.94 8.92 ± 1.22 11.38 ± 0.49
7l 13.55 ± 0.37 16.38 ± 0.31 9.36 ± 0.92 17.36 ± 0.24 9.90 ± 0.21 12.71 ± 0.79
7m 13.59 ± 1.88 16.82 ± 0.14 10.17 ± 1.15 16.06 ± 1.46 6.86 ± 0.63 11.54 ± 0.41
7n 13.65 ± 0.69 17.54 ± 0.52 17.31 ± 1.02 18.74 ± 0.31 12.50 ± 0.45 18.19 ± 0.84
C+ 25.00 ± 1.32 25.00 ± 0.98 25.00 ± 0.53
  1. Inhibition zone (IZ) ± standard deviation (SD); C+, positive control (Thiram); C−, negative control (DMSO)
  2. aMean of three assays