Skip to main content

Advertisement

Table 3 Human MAO inhibitory activity of caffeic acid derivatives

From: Hybrid caffeic acid derivatives as monoamine oxidases inhibitors: synthesis, radical scavenging activity, molecular docking studies and in silico ADMET analysis

Sr. no IC50 (µM)a hMAO-A IC50 (µM)a hMAO-B Selectivity indexb Docking score hMAO-A Docking score hMAO-B
1. 08.87 ± 0.005 42.34 ± 0.077 0.209 − 10.01 − 2.34
2. 08.51 ± 0.017 44.42 ± 0.014 0.191 − 11.11 − 3.45
3. 17.72 ± 0.006 21.14 ± 0.025 0.838 − 8.45 − 4.23
4. 18.47 ± 0.007 57.88 ± 0.029 0.319 − 7.12 − 3.87
5. 50.26 ± 0.035 10.80 ± 0.024 4.653 − 3.23 − 8.56
6. 20.36 ± 0.002 16.25 ± 0.035 1.252 − 6.56 − 7.53
7. 07.03 ± 0.022 24.14 ± 0.017 0.291 − 12.67 − 3.86
8. 19.75 ± 0.066 27.26 ± 0.072 0.724 − 6.12 − 5.34
9. 10.33 ± 0.012 27.25 ± 0.004 0.379 − 9.34 − 4.87
10. 25.22 ± 0.015 12.95 ± 0.046 1.947 − 4.72 − 8.45
11. 24.34 ± 0.011 21.48 ± 0.056 1.233 − 5.32 − 7.34
12. 22.02 ± 0.018 48.54 ± 0.077 0.453 − 6.27 − 3.86
Caffeic acid 11.72 ± 0.044 22.88 ± 0.009 0.512 − 10.63 − 7.53
Clorgyline 18.74 ± 0.096 − 5.773
Pargyline 20.04 ± 0.095 − 6.061
  1. aValues related for the evaluated compound absorption which provide 50% inhibition of MAO-A and MAO-B, action, and are the mean SEM; statistical significance: p < 0.05 against the equivalent IC50 values achieved against MAO-A and MAO-B, as identified through ANOVA/Dunnett’s test
  2. bSelectivity index = IC50 (MAO-A)/IC50 (MAO-B)