Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents

Table 4 In silico bioavailability prediction and cLogP value

Compd. no	In silico Bioavailability and cLogP				Bioavailability score
Compd. no	cLogP	Lipinski	Ghose	Veber	Bioavailability score
4a	3.19	Yes	No	No	0.55
4b	2.31	Yes	Yes	No	0.55
4c	3.24	Yes	Yes	No	0.55
4d	3.19	Yes	Yes	No	0.55
4e	3.34	Yes	No; 1 violation	No	0.55
4f	1.52	Yes	Yes	No	0.55
6a	4.11	No	No	No	0.17
6b	2.35	No	No	No	0.17
6c	4.20	No	No	No	0.17
6d	4.10	No	No	No	0.17
6e	4.41	No	No	No	0.17
6f	0.75	No	No	No	0.17
Cipro.	− 0.70	Yes	Yes	Yes	0.55
Fluco.	− 0.12	Yes	Yes	Yes	0.55

ISSN: 2661-801X