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Table 2 In vitro antiproliferative activities (IC50 represented as μM ± SD) of the newly synthesized compounds against three human cancer cell lines

From: Design, synthesis, ADME prediction and pharmacological evaluation of novel benzimidazole-1,2,3-triazole-sulfonamide hybrids as antimicrobial and antiproliferative agents

Compd. no

IC50 PC-3

IC50 HepG2

IC50 HEK293

4a

66

66

70

4b

61

62

65

4c

80

77

81

4d

90

91

92

4e

85

86

83

4f

104

106

103

6a

61

61

64

6b

55

56

59

6c

73

70

74

6d

82

83

84

6e

77

79

75

6f

95

97

95

  1. IC50 values are presented as mean values of three independent experiments. SD were < 10%