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Table 2 Synthesis of pyrimidine derivatives under optimum reaction conditions*

From: Magnetic core–shell Carrageenan moss/Fe3O4: a polysaccharide-based metallic nanoparticles for synthesis of pyrimidinone derivatives via Biginelli reaction

Entry R1 X R2 Product Time (min) Yield (%) Mp (°C)
Observed Reported [Refs]
1 4-Cl O Et 60 95 210–212 213–214 [14]
2 4-Me O Et 90 73 213–215 214–217 [15]
3 4-OMe O Et 90 87 200–202 202–203 [16]
4 2-NO2 O Et 60 85 220–221 220 [17]
5 3-NO2 O Et 45 76 214–216 217 [18]
6 H O Me 60 87 210–212 207–210 [19]
7 4-Cl O Me 60 85 205–207 204–206 [20]
8 4-OMe O Me 45 93 190–192 191–193 [19]
9 4-Cl S Me 60 90 154–155 153–156[21]
10 H S Me 60 90 225–227 226–228 [22]
11 4-Cl S Et 45 93 190–192 188–190 [21]
12 4-OMe S Et 60 88 152–154 151–153 [22]
13 3-NO2 S Et 60 90 205–207 202–204 [23]
  1. *Reaction catalyzed by Fe3O4@CM (20 mg) under reflux conditions in water