Magnetic core–shell Carrageenan moss/Fe3O4: a polysaccharide-based metallic nanoparticles for synthesis of pyrimidinone derivatives via Biginelli reaction

Table 1 Optimization of the reaction conditions (catalyst loading, solvent and temperature) for the synthesis of 4a

Entry	Condition/solvent	Catalyst (mg)	Temp (°C)	Time (min)	Yield (%)
1	H₂O	0	100	180	Trace
2	H₂O	10	100	90	87
3	H₂O	10	25	360	64
4	SF	10	50	240	70
5	Ultrasound/H₂O	10	25^b	90	85
6	EtOH	10	78	120	73
7	DMF	10	153	180	67
8	EtOAC	10	77	150	80
9	CHCl₂	10	61	240	63
10	Toluene	10	111	270	65
11*	H ₂ O	20	100	60	95
12	Ultrasound/H₂O	20	25	60	75
13	H₂O	30	100	60	95
14^a	H₂O	NMCM (10)	100	110	90

ISSN: 2661-801X