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Table 6 Cytotoxicity (IC50 = µM) of triarylethylene analogs (20–22)

From: Estrogen alpha receptor antagonists for the treatment of breast cancer: a review

Compound No. Cancer cell lines
MDA-MB-231 MCF-7
20 11.4 ± 4.2 16.9 ± 7.7
21 16.9 ± 7.7 > 50
22 12.2 ± 5.3 > 50
Tamoxifen > 50 50
Ospemifene > 50 > 50