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Table 16 In vitro antiproliferative activity of tetrahydroisoquinoline derivatives 48–50
From: Estrogen alpha receptor antagonists for the treatment of breast cancer: a review
| Compound No. | Tumor cell lines (IC50 = µg/ml) | ||
|---|---|---|---|
| Ishikawa | MCF-7 | MDA-MB-231 | |
| 48 | 0.08 | 0.2 | 0.13 |
| 49 | 0.09 | 0.61 | 1.36 |
| 50 | 0.11 | 0.25 | 0.23 |
| Tamoxifen | 7.87 | 3.99 | 7.85 |
