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Table 16 In vitro antiproliferative activity of tetrahydroisoquinoline derivatives 48–50

From: Estrogen alpha receptor antagonists for the treatment of breast cancer: a review

Compound No. Tumor cell lines (IC50 = µg/ml)
Ishikawa MCF-7 MDA-MB-231
48 0.08 0.2 0.13
49 0.09 0.61 1.36
50 0.11 0.25 0.23
Tamoxifen 7.87 3.99 7.85