Table 12 Anticancer activity and binding affinity of the synthesized derivatives 36–37
From: Estrogen alpha receptor antagonists for the treatment of breast cancer: a review
Compound no | Cancer cell line (IC50 = µM) | Binding affinity (nM) |
|---|---|---|
|  | T47D | ER-α |
36 | 16.51 ± 0.75 | 55 ± 1.97 |
37 | 17.94 ± 1.0 | 16.55 ± 1.95 |
Bazedoxifene | 16.43 ± 0.94 | 31.71 ± 1.41 |
Amino acid residues | ||
Met 343, Met 421, Leu 525, Met 522, Met 388, Leu 428, Ala 350, Leu 391, Leu 387, Ile 424, Leu 349, Leu 384, Trp 383, Leu 354, Pro 535, Leu 346, Leu 539, Val534 and Phe 404 | ||