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Table 4 Vandetanib cyano conjugates

From: Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

Code

MS scan

Major fragments

tR (min)

Metabolic pathway

Postulated conjugate composition

VB486

486

389.4, 363.2

71.6

α Cyano addition and N-demethylation

V − CH3 + CN

VB500a

500a

373.2, 137.1

68.4

α Cyano addition

V + CN

VB500b

500b

456.9, 163.9

76

N-demethylation, α oxidation and α Cyano addition

V − CH3 + CN + O

VB502

502

484.3, 361.3, 287.4, 203.1

77.1

N-demethylation, α hydroxylation and α Cyano addition

V − CH3 + CN + OH