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Table 4 Vandetanib cyano conjugates

From: Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

Code MS scan Major fragments tR (min) Metabolic pathway Postulated conjugate composition
VB486 486 389.4, 363.2 71.6 α Cyano addition and N-demethylation V − CH3 + CN
VB500a 500a 373.2, 137.1 68.4 α Cyano addition V + CN
VB500b 500b 456.9, 163.9 76 N-demethylation, α oxidation and α Cyano addition V − CH3 + CN + O
VB502 502 484.3, 361.3, 287.4, 203.1 77.1 N-demethylation, α hydroxylation and α Cyano addition V − CH3 + CN + OH