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Table 3 Phase I metabolites of Vandetanib using MS scan and PI scan

From: Identification and characterization of in vivo, in vitro and reactive metabolites of vandetanib using LC–ESI–MS/MS

  MS scan Major daughter ions tR (min) Metabolic pathway Proposed conjugate composition Previously detected (reference)
VNT 475 112 50.4   V + H  
VA461 461 364, 98 49.7 N-demethylation V − CH2 + H + [1]
VA475 475 112, 110 54.7 N-demethylation and α oxidation V − CH2 + O + H  
VA489a 489 126 66.8 α oxidation V + O − 2H + H  
VA489b 489 364 67.9 N-demethylation and 2 α oxidation V − CH2 + 2O + H  
VA491a 491 128, 111 57.1 α Hydroxylation V + O + H  
VA491b 491 189, 128 50.4 N-oxidation V + O + H + [1]