Skip to main content

Advertisement

Table 1 Antimicrobial activity (MIC and MMC in µg/mL) of extracts, isolated compounds and reference antimicrobial drugs

From: Antimicrobial activities of saponins from Melanthera elliptica and their synergistic effects with antibiotics against pathogenic phenotypes

Extracts/compounds Inhibition parameters E. coli S. flexneri S. aureus C. parapsilosis C. albicans C. neoformans
MeOH extract MIC 512 256 128 > 2048 > 2048 > 2048
MMC 1024 512 128 / / /
MMC/MIC 2 2 1 / / /
n-BuOH extract MIC 256 128 128 > 2048 > 2048 > 2048
MMC 512 256 128 / / /
MMC/MIC 2 2 1 / / /
EtOAc extract MIC 128 128 64 1024 1024 512
MMC 256 128 128 1024 1024 1024
MMC/MIC 2 1 2 1 1 2
1 MIC 32 16 8 32 64 16
MMC 32 32 16 64 64 16
MMC/MIC 1 2 2 2 1 1
2 MIC 32 16 16 > 256 > 256 32
MMC 32 32 16 / / 64
MMC/MIC 1 2 1 / / 2
3 MIC 128 64 32 128 128 32
MMC 256 128 64 256 256 64
MMC/MIC 2 2 2 2 2 2
4 MIC 256 128 64 16 16 8
MMC > 256 256 128 32 64 16
MMC/MIC / 2 2 2 4 1
Refa MIC 32 16 0.5 0.5 1 2
MMC 32 16 0.5 0.5 1 2
MMC/MIC 1 1 1 1 1 1
  1. /: not determined; MIC minimum inhibitory concentration, MMC minimum microbicidal concentration
  2. aFluconazole for yeasts and vancomycin for bacteria