Table 2 In vitro antimicrobial and anticancer screening of the synthesized derivatives (1–26)
From: Benzoxazole derivatives: design, synthesis and biological evaluation
Comp. no. | Antimicrobial screening (MIC = ×10−3 µM) | Anticancer screening (IC50 = µM) | ||||||
|---|---|---|---|---|---|---|---|---|
BS | PA | EC | ST | KP | AN | CA | HCT-116 | |
1 | 2.83 | 2.83 | 2.83 | 2.83 | 2.83 | 5.66 | 0.34 | 192.5 |
2 | 2.65 | 2.65 | 5.30 | 5.30 | 5.30 | 5.30 | 0.66 | 84.8 |
3 | 2.65 | 2.65 | 2.65 | 2.65 | 2.65 | 2.65 | 0.66 | > 212.1 |
4 | 2.49 | 4.98 | 2.49 | 4.98 | 2.49 | 2.49 | 0.62 | 39.9 |
5 | 2.49 | 4.98 | 4.98 | 2.49 | 2.49 | 4.98 | 1.25 | > 199.4 |
6 | 1.18 | 4.70 | 2.35 | 2.35 | 4.70 | 4.70 | 0.59 | 24.5 |
7 | 2.58 | 5.17 | 2.58 | 5.17 | 5.17 | 5.17 | 0.65 | > 206.8 |
8 | 2.45 | 4.91 | 4.91 | 4.91 | 4.91 | 4.91 | 0.61 | > 196.3 |
9 | 2.68 | 5.36 | 5.36 | 5.36 | 5.36 | 2.68 | 0.67 | > 214.4 |
10 | 1.14 | 4.57 | 2.28 | 4.57 | 4.57 | 4.57 | 0.57 | > 182.6 |
11 | 1.28 | 5.14 | 5.14 | 5.14 | 5.14 | 5.14 | 0.64 | > 205.5 |
12 | 2.57 | 5.14 | 5.14 | 5.14 | 2.57 | 5.14 | 1.28 | > 205.5 |
13 | 2.57 | 2.57 | 5.14 | 5.14 | 1.28 | 5.14 | 0.64 | > 205.5 |
14 | 2.63 | 2.63 | 2.63 | 5.25 | 1.31 | 5.25 | 0.66 | > 210.1 |
15 | 2.63 | 5.25 | 5.25 | 2.63 | 1.31 | 5.25 | 1.31 | > 210.1 |
16 | 1.22 | 4.90 | 2.45 | 4.90 | 1.22 | 4.90 | 1.22 | > 195.9 |
17 | 2.52 | 5.05 | 2.52 | 2.52 | 1.26 | 2.52 | 0.63 | > 201.8 |
18 | 2.72 | 5.44 | 2.72 | 2.72 | 1.36 | 5.44 | 5.44 | 78.3 |
19 | 2.40 | 4.80 | 4.80 | 2.40 | 4.80 | 2.40 | 4.80 | > 192.2 |
20 | 2.40 | 4.80 | 4.80 | 2.40 | 4.80 | 4.80 | 4.80 | > 192.2 |
21 | 2.60 | 5.20 | 2.60 | 2.60 | 5.20 | 2.60 | 5.20 | > 208.1 |
22 | 2.67 | 2.67 | 5.35 | 5.35 | 5.35 | 5.35 | 5.35 | 70.6 |
23 | 2.82 | 5.65 | 1.41 | 2.82 | 5.65 | 5.65 | 5.65 | > 226 |
24 | 2.79 | 5.59 | 1.40 | 2.79 | 2.79 | 2.79 | 2.79 | 96.1 |
25 | 2.71 | 5.42 | 2.71 | 2.71 | 5.42 | 2.71 | 2.71 | 45.5 |
26 | 2.73 | 2.73 | 2.73 | 2.73 | 5.46 | 5.46 | 5.46 | 35.6 |
Ofloxacin | 1.73 | 3.46 | 3.46 | 1.73 | 3.46 | – | – | – |
Fluconazole | – | – | – | – | – | 4.08 | 2.04 | – |
5-FU | – | – | – | – | – | – | – | 29.2 |