Design and synthesis of novel 3-(thiophen-2-yl)-1,5-dihydro-2H-pyrrol-2-one derivatives bearing a hydrazone moiety as potential fungicides

Table 2 EC₅₀ values of some title compounds against Rs, Cc and Fg

Compd.	Tested fungus	Regression equation	R	EC₅₀ (µg/mL)
5b	Rs	y = 0.76x + 4.73	0.99	2.28 ± 3.00
5b	Cc	y = 0.81x + 4.28	0.95	7.65 ± 5.31
5d	Rs	y = 1.42x + 3.57	0.98	5.23 ± 3.74
5d	Cc	y = 1.60x + 2.95	0.98	9.97 ± 8.90
5e	Rs	y = 0.87x + 4.91	0.99	1.26 ± 1.12
	Cc	y = 1.42x + 3.89	0.99	6.04 ± 5.35
	Fg	y = 2.32x + 3.17	0.97	6.13 ± 4.49
5f	Rs	y = 0.50x + 4.74	0.99	3.32 ± 2.74
	Cc	y = 1.25x + 3.97	0.99	6.66 ± 5.33
	Fg	y = 1.74x + 3.54	0.99	6.90 ± 4.96
5g	Rs	y = 0.38x + 4.77	0.96	4.13 ± 2.83
	Cc	y = 1.32x + 3.82	0.99	7.84 ± 7.03
	Fg	y = 1.25x + 3.87	0.96	8.03 ± 5.01
5n	Rs	y = 1.26x + 4.31	0.99	3.56 ± 3.16
5n	Cc	y = 1.35x + 3.81	0.97	7.59 ± 5.12
5o	Rs	y = 1.42x + 3.79	0.98	7.15 ± 5.62
	Cc	y = 1.47x + 3.56	0.99	9.47 ± 8.02
	Fg	y = 1.97x + 3.10	0.99	7.22 ± 6.01
5p	Rs	y = 2.41x + 3.49	0.99	2.22 ± 1.68
	Cc	y = 4.22x + 1.87	0.99	5.52 ± 5.49
	Fg	y = 3.56x + 2.04	0.98	6.77 ± 5.14
5q	Rs	y = 1.76x + 3.73	0.99	5.29 ± 4.54
	Cc	y = 1.68x + 3.29	0.99	6.41 ± 4.96
	Fg	y = 3.79x + 1.30	0.99	7.63 ± 5.81
5r	Rs	y = 1.13x + 3.70	0.98	9.89 ± 7.18
5r	Fg	y = 1.33x + 3.47	0.99	8.85 ± 8.26
5t	Rs	y = 1.27x + 3.81	0.99	8.62 ± 7.06
	Cc	y = 1.39x + 3.24	0.98	7.53 ± 6.89
	Fg	y = 1.37x + 3.85	0.97	6.02 ± 5.26
Drazoxolon ^a	Rs	y = 2.54x + 4.37	0.99	1.77 ± 1.62
	Cc	y = 0.82x + 3.94	0.99	19.46 ± 3.93
	Fg	y = 2.04x + 3.88	0.99	3.53 ± 2.72

Average of three replicates
^a A commercial agricultural fungicide drazoxolon was used for comparison of antifungal activity

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