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Scheme 1 | Chemistry Central Journal

Scheme 1

From: Facile synthesis of N- (4-bromophenyl)-1- (3-bromothiophen-2-yl)methanimine derivatives via Suzuki cross-coupling reaction: their characterization and DFT studies

Scheme 1

Synthesis of N-(4-bromophenyl)-1-(3-bromothiophen-2-yl)methanimine (3) and Suzuki coupling of imine with arylboronic acids. Conditions: (i) 1 (1.74 mmol, 0.3 g), 2 (1.74 mmol, 0.33 g), ethanol (10 ml), glacial acetic acid (5–6 drops). (ii) 3 (0.29 mmol, 0.1 g), arylboronic acid (0.32 mmol), K3PO4 (0.58 mmol,0.12 g), Pd(pph3)4 (1.45 mmol, 0.01 g), 1,4-dioxane:H2O (4:1), reflux 12 h, 95 °C, (iii) 3 (0.29 mmol, 0.1 g), arylboronic acid (0.80 mmol, 0.12 g), K3PO4 (0.58 mmol, 0.12 g), Pd(pph3)4 (1.45 mmol, 0.01 g), 1,4-dioxane:H2O (4:1), reflux 12 h, 95 °C

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