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Table 2 Assigned scores for the eight high content flavonoids in flavonoids-rich extract from S. baicalensis shoots

From: Inhibitory effects against α-glucosidase and α-amylase of the flavonoids-rich extract from Scutellaria baicalensis shoots and interpretation of structure–activity relationship of its eight flavonoids by a refined assign-score method

Flavonoids

Number of structural features

Total score of structural features

Double bond (10 scores)

C7-OH (4 scores)

C4′-OH (4 scores)

C6-OH (3 scores)

Sugar moiety (− 1 score)

Apigenin (1)a

7

1

1

0

0

78

Baicalein (2)

7

1

0

1

0

77

Scutellarin (3)

7

0

1

1

1

76

Chrysin (4)

7

1

0

0

0

74

Apigenin-7-O-G (5)

7

0

1

0

1

73

Baicalin (6)

7

0

0

1

1

72

Chrysin-7-O-G (7)

7

0

0

0

1

69

Isocarthamidin-7-O-G (8)

6

0

1

1

1

66

  1. G glucuronide
  2. aEight flavonoids are arranged in a decreasing order of inhibitory effects against both α-glucosidase and α-amylase