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Table 3 Well-known AchE inhibitors with the respective LD50 in comparison with compound 1

From: Crystal structure, DFT calculations and evaluation of 2-(2-(3,4-dimethoxyphenyl)ethyl)isoindoline-1,3-dione as AChE inhibitor

Inhibitors Compound LD50 (mice)
1 > 1600 mg/kg
Donepezil 30 mg/kg [41]
Physostigmine 3 mg/kg [42]
Neostigmine  0.54 ± 0.03 mg/kg [1]
Pyridostigmine 37.5 mg/kg [41]