Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene)bis(pyrimidin-2-amine) derivatives

Table 2 Antimicrobial activity results of synthesized bis-pyrimidine molecules

Compound no.	Antimicrobial activity (MIC = µmol/mL)						Fungal species
	Bacterial species
	Gram positive		Gram negative
	S.A.	B.C.	S.T.	P.A.	E.C.	P.R.	A.N.	A.F. ^a	A.F. ^b
s1.	0.16	0.08	–	–	0.25	0.16	0.63	1.26	–
s2.	2.36	1.18	–	2.36	–	2.36	2.36	1.18	0.59
s3.	0.61	0.61	–	–	–	0.15	0.61	1.22	0.61
s4.	0.16	0.08	0.33	0.16	0.26	0.16	2.63	0.66	0.16
s5.	0.59	0.59	–	–	–	0.15	–	1.18	1.18
s6.	–	0.15	2.44	1.22	0.61	–	2.44	0.61	0.15
s7.	0.61	–	1.22	0.61	2.44	0.08	–	1.22	–
s8.	–	1.23	0.31	0.15	0.61	–	2.46	0.61	0.15
s9.	0.16	0.08	0.32	0.16	0.25	0.16	–	–	0.32
s10.	1.27	0.63	1.27	2.54	–	0.63	0.63	1.27	0.32
s11.	0.14	0.07	0.29	1.16	0.23	0.14	0.58	–	0.14
s12.	1.27	0.63	–	2.54	–	0.63	–	1.27	0.32
s13.	1.22	0.61	–	–	1.22	0.61	1.22	1.22	–
s14.	2.51	1.26	–	1.26	–	2.51	–	0.31	0.63
s15.	0.66	0.66	–	–	0.66	0.16	0.66	0.33	–
s16.	0.57	0.57	–	–	0.57	0.14	2.30	0.57	0.14
s17.	–	0.16	2.51	1.26	0.63	1.26	0.63	0.31	1.26
s18.	0.64	–	1.28	0.64	2.56	0.08	1.28	–	0.32
Acetone	NA	NA	NA	NA	NA	NA	NA	NA	NA
Broth control	NG	NG	NG	NG	NG	NG	NG	NG	NG
*Std.*	0.34^c	0.34^c	0.68^c	0.68^c	0.34^c	0.68^c	0.82^d	0.82^d	0.82^d

S.A.: Staphylococcus aureus; B.C.: Bacillus cereus; S.T.: Salmonella typhi; P.A.: Pseudomonas aeruginosa; E.C.: Escherichia coli; P.R.: Providencia rettgeri; A.N.: Aspergillus niger
^aA.F.: Aspergillus fumigatus; ^bA.F.: Aspergillus flavus; Resistant (–); NA no activity, NG No growth
Std.: Cefadroxil^c; Fluconazole^d

ISSN: 2661-801X