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Table 2 Antimicrobial activity results of synthesized bis-pyrimidine molecules

From: Design, synthesis, antimicrobial and cytotoxicity study on human colorectal carcinoma cell line of new 4,4′-(1,4-phenylene)bis(pyrimidin-2-amine) derivatives

Compound no. Antimicrobial activity (MIC = µmol/mL) Fungal species
Bacterial species
Gram positive Gram negative
S.A. B.C. S.T. P.A. E.C. P.R. A.N. A.F. a A.F. b
s1. 0.16 0.08 0.25 0.16 0.63 1.26
s2. 2.36 1.18 2.36 2.36 2.36 1.18 0.59
s3. 0.61 0.61 0.15 0.61 1.22 0.61
s4. 0.16 0.08 0.33 0.16 0.26 0.16 2.63 0.66 0.16
s5. 0.59 0.59 0.15 1.18 1.18
s6. 0.15 2.44 1.22 0.61 2.44 0.61 0.15
s7. 0.61 1.22 0.61 2.44 0.08 1.22
s8. 1.23 0.31 0.15 0.61 2.46 0.61 0.15
s9. 0.16 0.08 0.32 0.16 0.25 0.16 0.32
s10. 1.27 0.63 1.27 2.54 0.63 0.63 1.27 0.32
s11. 0.14 0.07 0.29 1.16 0.23 0.14 0.58 0.14
s12. 1.27 0.63 2.54 0.63 1.27 0.32
s13. 1.22 0.61 1.22 0.61 1.22 1.22
s14. 2.51 1.26 1.26 2.51 0.31 0.63
s15. 0.66 0.66 0.66 0.16 0.66 0.33
s16. 0.57 0.57 0.57 0.14 2.30 0.57 0.14
s17. 0.16 2.51 1.26 0.63 1.26 0.63 0.31 1.26
s18. 0.64 1.28 0.64 2.56 0.08 1.28 0.32
Acetone NA NA NA NA NA NA NA NA NA
Broth control NG NG NG NG NG NG NG NG NG
Std. 0.34c 0.34c 0.68c 0.68c 0.34c 0.68c 0.82d 0.82d 0.82d
  1. S.A.: Staphylococcus aureus; B.C.: Bacillus cereus; S.T.: Salmonella typhi; P.A.: Pseudomonas aeruginosa; E.C.: Escherichia coli; P.R.: Providencia rettgeri; A.N.: Aspergillus niger
  2. aA.F.: Aspergillus fumigatus; bA.F.: Aspergillus flavus; Resistant (–); NA no activity, NG No growth
  3. Std.: Cefadroxilc; Fluconazoled