A facile synthesis, and antimicrobial and anticancer activities of some pyridines, thioamides, thiazole, urea, quinazoline, β-naphthyl carbamate, and pyrano[2,3-d]thiazole derivatives

Table 2 Mean zone of inhibition beyond well diameter (6 mm) produced on a range of clinically pathogenic microorganisms using a 5 mg mL⁻¹ concentration of tested samples

Compound no.	Aspergillus fumigatus (fungus)	Candida albicans (fungus)	Streptococcus pneumonia (Gram +ve bact.)	Bacillus subtilis (Gram +ve bact.)	Pseudomonas aeruginosa (Gram −ve bact.)	Escherichia coli (Gram −ve bact.)
2a	15.4	14.8	10.9	12.9	17.3	11.6
2b	17.4	13.9	11.9	20.8	11.3	10.9
2e	14.8	11.9	15.1	16.3	11.1	11.4
2f	18.7	16.9	13.9	14.2	12.8	10.8
3a	12.7	15.2	14.1	12.8	0	10.1
3b	12.8	16.4	15.1	12.7	11.4	9.1
3d	14.8	11.9	13.2	13.5	13.8	12.6
3e	18.4	10.9	12.6	13.2	10.1	10.9
3f	15.7	15.9	16.7	19.2	0	13.6
4a	0.0	0.0	9.2	10.5	0	0
4b	17.7	18.4	15.7	15.3	13.2	9.6
4c	12.2	10.5	11.6	12.6	11.9	10.1
4e	15.4	10.4	10.9	12.9	11.3	11.6
4f	15.7	13.8	17.9	18.2	0	12.9
6	16.2	12.5	16.8	14.6	12.1	12.8
11a	19.1	16.9	13.6	14.7	12.1	10.4
11b	14.8	16.3	15.1	16.3	11.1	11.4
12	18.4	16.3	12.6	13.2	10.1	10.9
13	20.8	16.8	13.1	10.8	13.4	12.3
Amphotericin B	23.7	25.4	–	–	–	–
Ampicillin	–	–	23.8	32.4	–	–
Gentamicin	–	–	–	–	17.3	19.9

Candida albicans and aspergillus fumigatus were resistant to compound 4a
Pseudomonas aeruginosa was resistant to compounds 3a, 3f, 4a, and 4f
Aspergillus fumigatus was susceptible to compounds to 2b, 2f, 3e, 4b, 11a, 12 and 13 while being moderate to 2a, 2e, 3a–3d, 3f, 4c, 4e–4f, 6, and 11b when compared to the Amphotericin B standard
Candida albicans was moderate to all compounds except 4a when compared to the Amphotericin B standard
Streptococcus pneumoniae was moderate to all compounds when compared to the Ampicillin standard
Bacillus subtilis was moderate to all compounds when compared to the Ampicillin standard
Pseudomonas aeruginosa was moderate to all compounds except compounds 3a, 3f, 4a, and 4f, which were resistant to when compared to their standard Gentamicin
Escherichia coli was moderate to all compounds except 4a, which was resistant when compared to the Gentamicin standard

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