Table 1 Cytotoxicity (IC50, μmol mL−1) of the synthesized compounds (3a–11b) against MCF-7 and HCT-116 human cancer cell lines
Compound no. | MCF-7 | HCT-116 | Compound no. | MCF-7 | HCT-116 |
|---|---|---|---|---|---|
IC50 (µmol mL−1) | IC50 (µmol mL−1) | IC50 (µmol mL−1) | IC50 (µmol mL−1) | ||
3a | 23.6 | 346 | 7 | 14.2 | > 500 |
4a | 13.5 | 291 | 8 | 23.5 | > 500 |
4d | 15.1 | 242 | 9 | 60.2 | 316 |
4e | 222 | 193 | 11a | 203 | 215 |
4f | 238 | 124 | 11b | 404 | 180 |
5 | 9.65 | 213 | |||
Imatinib | 24.5 | – | Imatinib | 24.5 | – |
Cisplatin | 2.43 | Cisplatin | 2.43 |