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Table 2 Inhibition percent of rat paw edema after administration of newly synthesized compounds

From: Heterocyclization of polarized system: synthesis, antioxidant and anti-inflammatory 4-(pyridin-3-yl)-6-(thiophen-2-yl) pyrimidine-2-thiol derivatives

Groups

0 h

1 h

2 h

3 h

4 h

Diclofenac sodium

0.49 ± 0.032a

30.22 ± 1.27a

33.85 ± 1.19a

36.21 ± 0.93a

41.10 ± 3.98a

Compound 3

5 mg/kg.b.wt

0.48 ± 0.027ab

21.72 ± 0.79b

22.79 ± 1.07d

24.79 ± 0.49c

28.41 ± 1.30c

Compound 3

10 mg/kg.b.wt

0.47 ± 0.04ab

31.98 ± 9.35a

29.93 ± 1.43b

34.16 ± 0.61b

41.15 ± 0.750a

Compound 4

5 mg/kg.b.wt

0.46 ± 0.03b

18.91 ± 1.19bc

20.07 ± 1.43e

21.96 ± 1.25d

27.38 ± 1.68c

Compound 4

10 mg/kg.b.wt

0.49 ± 0.01ab

21.43 ± 0.96b

26.27 ± 49e

33.13 ± 2.64b

37.15 ± 0.69b

Compound 5

5 mg/kg.b.wt

0.49 ± 0.01a

11.62 ± 1.24de

14.61 ± 1.81g

18.41 ± 1e

19.48 ± 0.89e

Compound 5

10 mg/kg.b.wt

0.48 ± 0.01ab

15.41 ± 0.83cd

18.83 ± 0.75ef

24.19 ± 1.59c

28.59 ± 2.26c

Compound 6

5 mg/kg.b.wt

0.50 ± 0.02a

9.61 ± 1.12e

12.28 ± 1.38h

17.19 ± 1.26e

18.51 ± 2.26e

Compound 6

10 mg/kg.b.wt

0.49 ± 0.01a

13.75 ± 1.15de

17.52 ± 1.13f

20.43 ± 0.65d

22.39 ± 1.16d

  1. Values are expressed as mean ± SD
  2. Different superscript letters are significantly different at P ≤ 0.05