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Table 2 Inhibition percent of rat paw edema after administration of newly synthesized compounds

From: Heterocyclization of polarized system: synthesis, antioxidant and anti-inflammatory 4-(pyridin-3-yl)-6-(thiophen-2-yl) pyrimidine-2-thiol derivatives

Groups 0 h 1 h 2 h 3 h 4 h
Diclofenac sodium 0.49 ± 0.032a 30.22 ± 1.27a 33.85 ± 1.19a 36.21 ± 0.93a 41.10 ± 3.98a
Compound 3 5 mg/kg.b.wt 0.48 ± 0.027ab 21.72 ± 0.79b 22.79 ± 1.07d 24.79 ± 0.49c 28.41 ± 1.30c
Compound 3 10 mg/kg.b.wt 0.47 ± 0.04ab 31.98 ± 9.35a 29.93 ± 1.43b 34.16 ± 0.61b 41.15 ± 0.750a
Compound 4 5 mg/kg.b.wt 0.46 ± 0.03b 18.91 ± 1.19bc 20.07 ± 1.43e 21.96 ± 1.25d 27.38 ± 1.68c
Compound 4 10 mg/kg.b.wt 0.49 ± 0.01ab 21.43 ± 0.96b 26.27 ± 49e 33.13 ± 2.64b 37.15 ± 0.69b
Compound 5 5 mg/kg.b.wt 0.49 ± 0.01a 11.62 ± 1.24de 14.61 ± 1.81g 18.41 ± 1e 19.48 ± 0.89e
Compound 5 10 mg/kg.b.wt 0.48 ± 0.01ab 15.41 ± 0.83cd 18.83 ± 0.75ef 24.19 ± 1.59c 28.59 ± 2.26c
Compound 6 5 mg/kg.b.wt 0.50 ± 0.02a 9.61 ± 1.12e 12.28 ± 1.38h 17.19 ± 1.26e 18.51 ± 2.26e
Compound 6 10 mg/kg.b.wt 0.49 ± 0.01a 13.75 ± 1.15de 17.52 ± 1.13f 20.43 ± 0.65d 22.39 ± 1.16d
  1. Values are expressed as mean ± SD
  2. Different superscript letters are significantly different at P ≤ 0.05