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Table 1 Display the anti-inflammatory activity of the newly synthesized compounds as IC 50, µM for COX-1, COX-2 and 5-LOX

From: Heterocyclization of polarized system: synthesis, antioxidant and anti-inflammatory 4-(pyridin-3-yl)-6-(thiophen-2-yl) pyrimidine-2-thiol derivatives

Group IC 50 (µM) COX-1 IC 50 (µM) COX-2 COX-1/COX-2 IC 50 (µM) 5 LOX
Celecoxib 5.47 0.86 7.91 N.D
Meclofenamate sodium ND ND ND 6.15
Compound 3 3.7 0.39 9.49 4.71
Compound 4 4.02 0.44 9.13 4.91
Compound 5 4.60 0.87 5.29 6.98
Compound 6 4.95 0.84 5.89 7.65