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Table 1 Display the anti-inflammatory activity of the newly synthesized compounds as IC 50, µM for COX-1, COX-2 and 5-LOX

From: Heterocyclization of polarized system: synthesis, antioxidant and anti-inflammatory 4-(pyridin-3-yl)-6-(thiophen-2-yl) pyrimidine-2-thiol derivatives

Group

IC 50 (µM)

COX-1

IC 50 (µM)

COX-2

COX-1/COX-2

IC 50 (µM)

5 LOX

Celecoxib

5.47

0.86

7.91

N.D

Meclofenamate sodium

ND

ND

ND

6.15

Compound 3

3.7

0.39

9.49

4.71

Compound 4

4.02

0.44

9.13

4.91

Compound 5

4.60

0.87

5.29

6.98

Compound 6

4.95

0.84

5.89

7.65