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Table 1 Regression and validation parameters of the proposed spectrophotometric methods for the determination of PAR, PSE and CET

From: Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold® capsules using spectrophotometric techniques

Parameters

RSDM method

SDR method

DRZC method

PCCA method

PAR

PSE

CET

PAR

PSE

CET

PAR

PSE

CET

PAR

PSE

CET

Linearity range (µg mL−1)

2.500–25.00

100.0–1100

2.000–50.00

2.500–25.00

100.0–1200

2.000–45.00

2.500–25.00

100.0–1200

2.000–45.00

2.500 –25.00

100.0 –900.0

5.000–50.00

Slope

5.500 × 10−3

1.740 × 10−2

5.620 × 10−1

2.930 × 10−1

2.860 × 10−2

4.600 × 10−1

5.500 × 10−3

1.100 × 10−3

2.610 × 10−2

6.160 × 10−2

9.000 × 10−4

3.140 × 10−2

Intercept

1.100  × 10−3

2.130 × 10−1

2.560 × 10−1

2.930 × 10−1

1.630 × 10−2

1.560  × 10−1

7.000 × 10−4

2.200 × 10−3

9.000 × 10−4

6.000 × 10−3

6.100  × 10−3

7.900  × 10−3

SE of slope

1.210 × 10−5

8.140 × 10−5

3.060  × 10−3

1.100 × 10−1

1.680 × 10−4

1.650 × 10−3

3.030 × 10−5

7.150 × 10−6

8.660 × 10−5

6.850 × 10−4

4.270 × 10−6

5.310 × 10−5

SE of intercept

2.040 × 10−4

5.620 × 10−2

9.270 × 10−2

1.740

1.300 × 10−1

4.770 × 10−2

4.980 × 10−4

5.430 × 10−3

2.730 × 10−3

1.040 × 10−2

2.69 × 10−3

1.70 × 10−3

Correlation coefficient (r)

1.000

1.000

1.000

1.0000

1.000

1.0000

1.000

1.000

1.000

1.000

1.000

1.000

Accuracy (n = 6) mean ± SD

100.4 ± 0.8000

99.40 ± 0.3900

100.1 ± 0.8700

99.57 ± 1.090

99.88 ± 1.280

100.2 ± 0.7100

100.9 ± 0.7100

99.68 ± 1.090

100.1 ± 0.6300

100.7 ± 1.529

98.82 ± 0.5310

100.4 ± 0.3980

Precision (n = 3 × 3) (RSD %)a

Repeatability intermediate precision

0.07800

1.220

0.05280

1.010

0.07700

1.230

0.5280

0.9050

0.09100

0.8370

0.1550

1.300

0.07800

1.220

0.2250

0.4290

0.2200

0.5200

0.1560

0.8810

0.2260

0.9970

0.1140

0.8000

LODb

0.1520

12.91

0.6570

0.2850

17.42

0.4470

0.3760

23.13

0.3690

0.6430

9.900

0.2210

LOQb

0.4610

39.11

1.990

0.8640

52.78

1.350

1.140

70.08

1.120

1.948

30.00

0.6690

  1. aRelative standard deviations (RSD) of three concentrations, the concentrations were as follows: PAR (5.000, 10.00, 25.00 µg mL−1), PSE (100.0, 600.0, 1000 µg mL−1) and CET (5.000, 15.00, 35.00 µg mL−1)
  2. bLOD = 3.3 × Standard deviation of residuals/slope; LOQ = 10 × Standard deviation of residuals/slope