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Table 1 Regression and validation parameters of the proposed spectrophotometric methods for the determination of PAR, PSE and CET

From: Analysis of paracetamol, pseudoephedrine and cetirizine in Allercet Cold® capsules using spectrophotometric techniques

Parameters RSDM method SDR method DRZC method PCCA method
PAR PSE CET PAR PSE CET PAR PSE CET PAR PSE CET
Linearity range (µg mL−1) 2.500–25.00 100.0–1100 2.000–50.00 2.500–25.00 100.0–1200 2.000–45.00 2.500–25.00 100.0–1200 2.000–45.00 2.500 –25.00 100.0 –900.0 5.000–50.00
Slope 5.500 × 10−3 1.740 × 10−2 5.620 × 10−1 2.930 × 10−1 2.860 × 10−2 4.600 × 10−1 5.500 × 10−3 1.100 × 10−3 2.610 × 10−2 6.160 × 10−2 9.000 × 10−4 3.140 × 10−2
Intercept 1.100  × 10−3 2.130 × 10−1 2.560 × 10−1 2.930 × 10−1 1.630 × 10−2 1.560  × 10−1 7.000 × 10−4 2.200 × 10−3 9.000 × 10−4 6.000 × 10−3 6.100  × 10−3 7.900  × 10−3
SE of slope 1.210 × 10−5 8.140 × 10−5 3.060  × 10−3 1.100 × 10−1 1.680 × 10−4 1.650 × 10−3 3.030 × 10−5 7.150 × 10−6 8.660 × 10−5 6.850 × 10−4 4.270 × 10−6 5.310 × 10−5
SE of intercept 2.040 × 10−4 5.620 × 10−2 9.270 × 10−2 1.740 1.300 × 10−1 4.770 × 10−2 4.980 × 10−4 5.430 × 10−3 2.730 × 10−3 1.040 × 10−2 2.69 × 10−3 1.70 × 10−3
Correlation coefficient (r) 1.000 1.000 1.000 1.0000 1.000 1.0000 1.000 1.000 1.000 1.000 1.000 1.000
Accuracy (n = 6) mean ± SD 100.4 ± 0.8000 99.40 ± 0.3900 100.1 ± 0.8700 99.57 ± 1.090 99.88 ± 1.280 100.2 ± 0.7100 100.9 ± 0.7100 99.68 ± 1.090 100.1 ± 0.6300 100.7 ± 1.529 98.82 ± 0.5310 100.4 ± 0.3980
Precision (n = 3 × 3) (RSD %)a
Repeatability intermediate precision
0.07800
1.220
0.05280
1.010
0.07700
1.230
0.5280
0.9050
0.09100
0.8370
0.1550
1.300
0.07800
1.220
0.2250
0.4290
0.2200
0.5200
0.1560
0.8810
0.2260
0.9970
0.1140
0.8000
LODb 0.1520 12.91 0.6570 0.2850 17.42 0.4470 0.3760 23.13 0.3690 0.6430 9.900 0.2210
LOQb 0.4610 39.11 1.990 0.8640 52.78 1.350 1.140 70.08 1.120 1.948 30.00 0.6690
  1. aRelative standard deviations (RSD) of three concentrations, the concentrations were as follows: PAR (5.000, 10.00, 25.00 µg mL−1), PSE (100.0, 600.0, 1000 µg mL−1) and CET (5.000, 15.00, 35.00 µg mL−1)
  2. bLOD = 3.3 × Standard deviation of residuals/slope; LOQ = 10 × Standard deviation of residuals/slope