4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studies

Table 1 Anti-bacterial and anti-tuberculosis activities (MIC, μg/mL) of coumarin hybrids (SKYa–SKYg)

Compounds	E. coli	E. aerogenes	S. typhi	S. pneumoniae	S. aureus	M. tuberculosis
SKYa	208	208	208	208	208	83
SKYb	82	82	82	41	165	132
SKYc	99	99	99	197	197	158
SKYd	189	189	189	94	378	151
SKYe	189	94	189	189	378	151
SKYf	189	189	378	189	378	151
SKYg	361	722	361	361	722	–
Streptomycin	31.25	62.5	62.5	31.25	31.25	–
Kanamycin	62.5	62.5	62.5	62.5	125	–
Vancomycin	250	125	125	31.25	31.25	–
Isoniazid	–	–	–	–	–	0.0781

Results are mean of triplicate values (n = 3)
Italic values indicate standard use
– Not applicable
No inhibition observed after highest test concentration of 50 μg/mL for M. tuberculosis

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