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Table 1 Anti-bacterial and anti-tuberculosis activities (MIC, μg/mL) of coumarin hybrids (SKYaSKYg)

From: 4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studies

Compounds E. coli E. aerogenes S. typhi S. pneumoniae S. aureus M. tuberculosis
SKYa 208 208 208 208 208 83
SKYb 82 82 82 41 165 132
SKYc 99 99 99 197 197 158
SKYd 189 189 189 94 378 151
SKYe 189 94 189 189 378 151
SKYf 189 189 378 189 378 151
SKYg 361 722 361 361 722
Streptomycin 31.25 62.5 62.5 31.25 31.25
Kanamycin 62.5 62.5 62.5 62.5 125
Vancomycin 250 125 125 31.25 31.25
Isoniazid 0.0781
  1. Results are mean of triplicate values (n = 3)
  2. Italic values indicate standard use
  3. – Not applicable
  4. No inhibition observed after highest test concentration of 50 μg/mL for M. tuberculosis