Scheme 1From: 4-Thiazolidinone coumarin derivatives as two-component NS2B/NS3 DENV flavivirus serine protease inhibitors: synthesis, molecular docking, biological evaluation and structure–activity relationship studiesSynthesis of acetyl coumarin (3a–3g) and coumarin thiosemicarbazones (5a–5g). Reagent and reaction conditions: (i) piperidine, 0–5 °C (ii) CH3COOH, CH3OH, refluxBack to article page