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Table 4 Pharmacokinetic parameters of DOX after single oral dose of DOX-S and PEGylated-DOX-PLGA-NPs (mean ± SD; n = 6)

From: Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

Parameters Cmax (ng/ml) Tmax (h) t1/2 AUC0−t (ng h/ml) AUC0−∞ (ng h/ml) Keli (h−1) Rel Bio
DOX-S 206.2 2.00 17.08 2130.75 3232.49 0.04  
PEGylated-DOX-PLGA-NPs 1398.19*** 2.00 36.64 20577.90*** 44664.33*** 0.02 9.7
  1. Rel Bio relative bioavailability
  2. ** p < 0.01
  3. *** p < 0.001