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Table 4 Pharmacokinetic parameters of DOX after single oral dose of DOX-S and PEGylated-DOX-PLGA-NPs (mean ± SD; n = 6)

From: Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

Parameters

Cmax (ng/ml)

Tmax (h)

t1/2

AUC0−t (ng h/ml)

AUC0−∞ (ng h/ml)

Keli (h−1)

Rel Bio

DOX-S

206.2

2.00

17.08

2130.75

3232.49

0.04

 

PEGylated-DOX-PLGA-NPs

1398.19***

2.00

36.64

20577.90***

44664.33***

0.02

9.7

  1. Rel Bio relative bioavailability
  2. ** p < 0.01
  3. *** p < 0.001