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Table 1 Precision and accuracy data for doxorubicin (DOX)

From: Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

Intra-batch Inter-batch
QC ID Theoretical content (ng/ml) Mean concentration observed (ng/ml) Accuracya (%) CVb (%) Mean concentration observed (ng/ml) Accuracya (%) CVb (%)
LOQQC 1.01 0.98 ± 0.012 97.03 1.22 0.95 ± 0.020 94.06 2.11
LQC 2.90 2.85 ± 0.060 98.28 2.11 2.83 ± 0.066 97.59 2.33
MQC 1000.00 981.04 ± 15.04 98.10 1.53 977.37 ± 16.01 97.74 1.64
HQC 2000.00 1978.89 ± 23.93 98.94 1.21 1971.05 ± 21.67 98.55 1.10
  1. Values (Mean ± SD) are derived from 6 replicates:
  2. a Accuracy (%) = Mean value of [(mean observed concentration)/(theoretical concentration)] × 100
  3. b Precision (%): coefficient of variance (percentage) = standard deviation divided by mean concentration found × 100; Theoretical contents; LOQQC: 1.01 ng/ml, LQC: 2.90 ng/ml; MQC: 1000 ng/ml; and HQC: 2000 ng/ml