Enhancement of oral bioavailability of doxorubicin through surface modified biodegradable polymeric nanoparticles

BMC Chemistry

Table 1 Precision and accuracy data for doxorubicin (DOX)

Intra-batch					Inter-batch
QC ID	Theoretical content (ng/ml)	Mean concentration observed (ng/ml)	Accuracy^a (%)	CV^b (%)	Mean concentration observed (ng/ml)	Accuracy^a (%)	CV^b (%)
LOQQC	1.01	0.98 ± 0.012	97.03	1.22	0.95 ± 0.020	94.06	2.11
LQC	2.90	2.85 ± 0.060	98.28	2.11	2.83 ± 0.066	97.59	2.33
MQC	1000.00	981.04 ± 15.04	98.10	1.53	977.37 ± 16.01	97.74	1.64
HQC	2000.00	1978.89 ± 23.93	98.94	1.21	1971.05 ± 21.67	98.55	1.10

Values (Mean ± SD) are derived from 6 replicates:
^a Accuracy (%) = Mean value of [(mean observed concentration)/(theoretical concentration)] × 100
^b Precision (%): coefficient of variance (percentage) = standard deviation divided by mean concentration found × 100; Theoretical contents; LOQQC: 1.01 ng/ml, LQC: 2.90 ng/ml; MQC: 1000 ng/ml; and HQC: 2000 ng/ml

ISSN: 2661-801X