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Table 4 In vivo phase II MST metabolites

From: Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry

 

Mass scan

Daughter ions

Retention time (min)

Phase II metabolic pathway

MG1

675

499, 399

18.93

Direct N-conjugation with glucuronic acid

MG2

661

485

18.77

N-demethylation and direct N-conjugation with glucuronic acid

MG3

691

514.8

18.7

Glucuronidation of hydroxy MST at N-methyl piperazine ring

MG4

691

515.3, 414.9

19.46

Glucuronidation of hydroxy MST at benzyl carbon