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Table 4 In vivo phase II MST metabolites

From: Characterization of in vivo metabolites in rat urine following an oral dose of masitinib by liquid chromatography tandem mass spectrometry

  Mass scan Daughter ions Retention time (min) Phase II metabolic pathway
MG1 675 499, 399 18.93 Direct N-conjugation with glucuronic acid
MG2 661 485 18.77 N-demethylation and direct N-conjugation with glucuronic acid
MG3 691 514.8 18.7 Glucuronidation of hydroxy MST at N-methyl piperazine ring
MG4 691 515.3, 414.9 19.46 Glucuronidation of hydroxy MST at benzyl carbon