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Table 1 The IC50 values represent the compound concentration (μM) required to inhibit A549 tumor cell proliferation by 50%

From: Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent

Compounds

IC50 (µM)

Compounds

IC50 (µM)

5a

26.8 ± 1.3

6c

81.5 ± 4.3

5b

54.7 ± 2.1

6d

379.4 ± 24.8

5c

74.3 ± 5.1

6e

53.8 ± 3.5

5d

238.7 ± 12.5

7a

60.5 ± 2.6

5e

49.3 ± 4.1

7b

104.6 ± 4.8

5f

60.2 ± 3.2

8

28.4 ± 1.6

6a

107.1 ± 6.2

9

26.3 ± 0.9

6b

3.6 ± 0.2

11

123 ± 6.1

Toxoflavina

0.7 ± 0.1

a5-FU

10.5 ± 0.1

  1. aReference drugs; 5-FU (5-fluorouracil)