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Table 1 The IC50 values represent the compound concentration (μM) required to inhibit A549 tumor cell proliferation by 50%

From: Synthesis and anticancer evaluation of some novel pyrimido[5,4-e][1,2,4]triazines and pyrazolo[3,4-d]pyrimidine using DMF-DMA as methylating and cyclizing agent

Compounds IC50 (µM) Compounds IC50 (µM)
5a 26.8 ± 1.3 6c 81.5 ± 4.3
5b 54.7 ± 2.1 6d 379.4 ± 24.8
5c 74.3 ± 5.1 6e 53.8 ± 3.5
5d 238.7 ± 12.5 7a 60.5 ± 2.6
5e 49.3 ± 4.1 7b 104.6 ± 4.8
5f 60.2 ± 3.2 8 28.4 ± 1.6
6a 107.1 ± 6.2 9 26.3 ± 0.9
6b 3.6 ± 0.2 11 123 ± 6.1
Toxoflavina 0.7 ± 0.1 a5-FU 10.5 ± 0.1
  1. aReference drugs; 5-FU (5-fluorouracil)