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Table 6 Cytotoxicity of compounds 15, 16, 17, 18, 19, 20 and Doxorubicin against breast carcinoma cell line MCF-7

From: Design, synthesis and evaluation of anticancer activity of novel 2-thioxoimidazolidin-4-one derivatives bearing pyrazole, triazole and benzoxazole moieties

Concentration µg/mL

Viability (%)/compound

15

16

17

18

19

20

Doxorubicin

500

8.76

5.28

7.95

6.17

5.21

8.25

1.51

250

13.81

13.96

21.34

13.92

11.36

16.37

2.36

125

26.92

21.47

30.67

21.40

20.84

28.72

3.21

62.5

37.24

32.68

38.72

28.57

27.30

41.89

5.07

31.25

48.17

36.43

51.90

36.71

35.26

49.78

6.93

15.6

60.95

42.90

64.18

48.86

39.48

80.93

15.46

7.8

76.43

51.72

72.37

69.52

46.29

92.34

19.89

3.9

89.71

69.37

88.45

81.94

54.68

97.28

24.98

2

97.02

83.19

92.32

90.68

69.31

100

31.69

1

100

92.48

97.45

96.25

80.47

100

40.17

0

100

100

100

100

100

100

100