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Table 2 Binding parameters for the interaction between active components in TCMs and plasma proteins

From: Study on the interaction between active components from traditional Chinese medicine and plasma proteins

Type

Compounds

Protein

K (M−1)

Stoichiometry

(n)

Quenching mechanism

Binding site

r

(nm)

Driving force

References

 

Flavone

BSA

2.139 × 104

2.26

 

IIA

 

a, b

[91]

 

Rutin

HSA

3.8 × 104

1.43

Static

IIA

 

a, b

[167]

 

Quercitrin

BSA

4.13 × 103

2.32

 

IIA

 

b, c

[91]

 

Kaempferol

HSA

2.89 × 105

0.65

Static

IIA

2.7

c

[124]

 

(+)-catechin

BSA

1.565 × 104

2.17

Static

IIA

 

a, b

[162]

 

Loureirin A

HSA

1.291 × 105

0.88

Static

IIA

2.66

c, d

[168]

 

Cochinchinenin C

HSA

2.532 × 105

0.78

Static

IIA

2.975

c, d

[168]

 

Hesperitin

HSA

1.29 × 105

1.03

Static

IIA

1.978

a, c

[123]

 

Diosmetin

HSA

1.18 × 105

0.84

Static

IIA

3.54

a, c

[136]

 

Apigenin

BSA

6.978 × 106

1.266

Static

IIA

1.89

a, c

[169]

  

HSA

9.83 × 104

0.8774

Static

IIA

3.21

a, b

[138]

 

Farrerol

HSA

4.76 × 105

0.46

Static

IIA

2.63

a, c

[170]

 

Baicalein

HSA

1.73 × 105

 

Static

IIA

2.04

a, c

[171]

Flavonoids

Delphinidin-3-O-glucoside

BSA

1.98 × 105

1.100

Static

IIA

2.81

c, d

[116]

  

HSA

1.443 × 105

1.082

 

IIA

2.34

a

[135]

 

Pelargonidin-3-O-glucoside

HSA

6.89 × 104

0.995

Static, dynamic

IIA

2.83

c, d

[135]

  

BSA

1.21 × 105

1.057

Static

IIA

2.74

b

[172]

 

Cyanidin-3-O-glucoside

HSA

1.096 × 105

1.042

Static, dynamic

IIA

2.58

b

[135]

 

Neohesperidin dihydrochalcone

HSA

2.79 × 104

1.02

Static

IIA

 

c, d

[117]

 

Icariin

HSA

3.0335 × 104

1.0282

Static

IIA

2.5

c, d

[133]

 

Guaijaverin

HSA

2.02 × 105

1.121

Static

IIA

2.527

a, b, c

[173]

 

Mangiferin

BSA

3.18 × 104

1.16

Static

IIA

 

a, c

[154]

 

Berberine

BSA

7.75 × 104

0.92

Static

IIA

 

b, c, d

[174]

 

Palmatine

BSA

7.11 × 104

1.17

Static

IIA

 

b, c, d

[174]

 

Paclitaxel

HSA

3.241 × 102

0.93

Static

IIA

2.23

a

[119]

Alkaloids

Tetrandrine

BSA

1.06 × 106

1.17

Static, dynamic

IIA

1.455

a, b

[120]

  

HSA

1.59 × 106

1.21

Static, dynamic

IIA

1.451

a

[120]

 

Brucine

BSA

3.47 × 105

1.04

Static

IIA

5.08

a, b

[175]

Triterpenes

Glycyrrhetinic acid

HSA

K1 = 1.65 × 105

K2 = 0.458 × 105

N1 = 0.43

N2 = 0.73

Static

IIA

 

1. c

2. a

[121]

 

Trans-feruloyl maslinic acid

HSA

1.42 × 108

0.6

 

IB

  

[129]

Phenyl-propanolds

Ferulic acid

HSA

7.87 × 103

 

Static

IIIA

 

c

[118]

 

Caffeic acid

BSA

4.264 × 105

1.173

Static

 

1.86

c

[118]

 

Chlorogenic acid

HSA

3.004 × 104

1.14

Static

Site I

3.10

b

[176]

 

Paeonol

HSA

4.84 × 103

  

IIIA

 

c, d

[85]

 

Curcumin

HSA

1.80 × 105

1.14

Static

IIA

 

c, d

[144]

Other phenolic substances

Salicylic acid

BSA

5.60 × 103

1.85

   

c, d

[79]

 

N-trans-p-coumaroyltyramine

HSA

4.5 × 105

1.538

 

IIA

 

a

[128]

 

Syringin

HSA

2.97 × 104

1.336

Static, dynamic

IIA

3.15

a

[121]

  1. K is equilibrium binding constant. Stoichiometry (N) is the number of binding sites considered for the fit. r is the distance between the Trp residue of HSA and the acceptor molecule. Driving force is noncovalent interactions between drugs and biological macromolecules, and a is hydrophobic interaction, b is electrostatic interaction, c is hydrogen bonds and d is van der Walls force
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BMC Chemistry

ISSN: 2661-801X

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