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Table 1 The relationship between thermodynamic parameters and binding forces

From: Study on the interaction between active components from traditional Chinese medicine and plasma proteins

Thermodynamic parameter Binding force
S > 0 May be hydrophobic and electrostatic interactions
S < 0 May be hydrogen bonds and van der Waals forces
H > 0, ∆S > 0 Hydrophobic interactions
H < 0, ∆S < 0 Hydrogen bonds and van der Waals forces
H ≈ 0 or very small, ∆S > 0 Electrostatic interactions