Table 1 The relationship between thermodynamic parameters and binding forces
Thermodynamic parameter | Binding force |
|---|---|
∆S > 0 | May be hydrophobic and electrostatic interactions |
∆S < 0 | May be hydrogen bonds and van der Waals forces |
∆H > 0, ∆S > 0 | Hydrophobic interactions |
∆H < 0, ∆S < 0 | Hydrogen bonds and van der Waals forces |
∆H ≈ 0 or very small, ∆S > 0 | Electrostatic interactions |