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Table 3 Dilution integrity and incurred samples

From: Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

 

Dilution integrity

Incurred samples

Human plasma

RLMS

Human plasma

RMLs

Conc. (ng/ml)

Conc. (ng/ml)

Conc. (ng/ml)

Conc. (ng/ml)

450

225

450

225

15

150

400

15

150

400

Mean

431.1

221.35

438

221.5

14.6

146.6

391.1

14.77

147.2

393.1

SD

16.24

3.74

2.50

1.85

0.39

2.82

7.17

0.45

1.89

4.77

RSD (%)

3.76

1.68

10.9

4.105

2.65

1.92

1.83

3.02

1.28

1.21

R (%)

95.8

98.37

97.3

98.4

99.3

101.8

100.7

98.44

98.17

98.28

RE (%)

− 4.2

1.63

− 2.6

1.52

− 6.5

1.82

0.75

1.57

− 3.73

− 3.28

  1. n = 6