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Table 3 Dilution integrity and incurred samples

From: Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

  Dilution integrity Incurred samples
Human plasma RLMS Human plasma RMLs
Conc. (ng/ml) Conc. (ng/ml) Conc. (ng/ml) Conc. (ng/ml)
450 225 450 225 15 150 400 15 150 400
Mean 431.1 221.35 438 221.5 14.6 146.6 391.1 14.77 147.2 393.1
SD 16.24 3.74 2.50 1.85 0.39 2.82 7.17 0.45 1.89 4.77
RSD (%) 3.76 1.68 10.9 4.105 2.65 1.92 1.83 3.02 1.28 1.21
R (%) 95.8 98.37 97.3 98.4 99.3 101.8 100.7 98.44 98.17 98.28
RE (%) − 4.2 1.63 − 2.6 1.52 − 6.5 1.82 0.75 1.57 − 3.73 − 3.28
  1. n = 6