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Table 1 Back calculation of conivaptan

From: Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

Conc. (ng/ml) Human plasma RLMs
Mean SD RSD R (%) RE (%) Mean SD RSD R (%) RE (%)
5.00 4.95 0.15 2.99 98.90 − 1.10 5.05 0.12 2.43 100.95 0.95
10.00 9.95 0.41 4.15 99.54 − 0.46 10.17 0.37 3.69 101.65 1.65
20.00 19.55 0.53 2.73 97.73 − 2.27 19.96 0.35 1.74 99.79 − 0.21
30.00 29.49 0.83 2.81 98.30 − 1.70 30.11 0.67 2.23 100.38 0.38
50.00 49.24 1.09 2.21 98.47 − 1.53 50.28 0.56 1.12 100.56 0.56
100.00 97.88 1.40 1.43 97.88 − 2.12 99.97 1.28 1.28 99.97 − 0.03
300.00 292.62 4.16 1.42 97.54 − 2.46 298.84 1.67 0.56 99.61 − 0.39
500.00 489.50 8.79 1.80 97.90 − 2.10 499.89 3.39 0.68 99.98 − 0.02