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Table 1 Back calculation of conivaptan

From: Development and validation of an HPLC–MS/MS method for the determination of arginine-vasopressin receptor blocker conivaptan in human plasma and rat liver microsomes: application to a metabolic stability study

Conc. (ng/ml)

Human plasma

RLMs

Mean

SD

RSD

R (%)

RE (%)

Mean

SD

RSD

R (%)

RE (%)

5.00

4.95

0.15

2.99

98.90

− 1.10

5.05

0.12

2.43

100.95

0.95

10.00

9.95

0.41

4.15

99.54

− 0.46

10.17

0.37

3.69

101.65

1.65

20.00

19.55

0.53

2.73

97.73

− 2.27

19.96

0.35

1.74

99.79

− 0.21

30.00

29.49

0.83

2.81

98.30

− 1.70

30.11

0.67

2.23

100.38

0.38

50.00

49.24

1.09

2.21

98.47

− 1.53

50.28

0.56

1.12

100.56

0.56

100.00

97.88

1.40

1.43

97.88

− 2.12

99.97

1.28

1.28

99.97

− 0.03

300.00

292.62

4.16

1.42

97.54

− 2.46

298.84

1.67

0.56

99.61

− 0.39

500.00

489.50

8.79

1.80

97.90

− 2.10

499.89

3.39

0.68

99.98

− 0.02