C. no.
|
R1, R2
|
Y
|
Mol. wt
|
Rf valuea
|
M. Pt.
|
IC50 (µM)b
|
---|
1
|
H, H
|
–COC6H5
|
393.443
|
0.57
|
210
|
13.1 ± 0.2
|
2
|
H, H
|
–COCH2CH2CH3
|
359.426
|
0.51
|
121–123
|
12.5 ± 0.9
|
3
|
H, H
|
–COCH3
|
331.372
|
0.46
|
164
|
17.8 ± 0.5
|
4
|
H, H
|
–COCH2CH3
|
345.399
|
0.55
|
190
|
13.5 ± 0.7
|
5
|
3-OH
|
–COCH3
|
347.371
|
0.47
|
123
|
13.9 ± 0.6
|
6
|
3-OH
|
–COCH2CH3
|
361.398
|
0.52
|
125–127
|
11.2 ± 0.6
|
7
|
3-OH
|
–COC6H5
|
409.442
|
0.50
|
230–231.5
|
8.5 ± 0.8
|
8
|
3-OH
|
–COCH2CH2CH3
|
375.425
|
0.60
|
255–255.3
|
7.7 ± 0.5
|
9
|
4-OH
|
–COCH3
|
347.371
|
0.56
|
124–125
|
13.6 ± 0.4
|
10
|
4-OH
|
–COCH2CH3
|
361.398
|
0.80
|
135
|
12.8 ± 0.9
|
11
|
4-OH
|
–COC6H5
|
409.442
|
0.48
|
232–233
|
11.1 ± 0.7
|
12
|
4-OH
|
–COCH2CH2CH3
|
375.425
|
0.30
|
251–252
|
10.3 ± 0.7
|
13
|
3, 4-di OH
|
–COCH3
|
363.370
|
0.75
|
180
|
11.8 ± 0.6
|
14
|
3, 4-di OH
|
–COCH2CH3
|
377.397
|
0.40
|
200
|
10.1 ± 0.5
|
15
|
3, 4-di OH
|
–COC6H5
|
425.441
|
0.65
|
240–242
|
8.2 ± 0.7
|
16
|
3, 4-di OH
|
–COCH2CH2CH3
|
391.424
|
0.75
|
266
|
7.3 ± 0.3
|
Pacc
|
–
|
–
|
–
|
–
|
–
|
7.3 ± 0.7
|
- aMobile phase: dichloromethane: methanol (19:1)
- bMean ± S.D. (n = 3)
- cPac—Paclitaxel