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Table 1 Physiochemical properties of synthesized diazepine substituted cinnamic acid derivatives and cytotoxicity evaluation on A549 cell lines

From: Targeting matrix metalloproteinases with novel diazepine substituted cinnamic acid derivatives: design, synthesis, in vitro and in silico studies

C. no. R1, R2 Y Mol. wt Rf valuea M. Pt. IC50 (µM)b
1 H, H –COC6H5 393.443 0.57 210 13.1 ± 0.2
2 H, H –COCH2CH2CH3 359.426 0.51 121–123 12.5 ± 0.9
3 H, H –COCH3 331.372 0.46 164 17.8 ± 0.5
4 H, H –COCH2CH3 345.399 0.55 190 13.5 ± 0.7
5 3-OH –COCH3 347.371 0.47 123 13.9 ± 0.6
6 3-OH –COCH2CH3 361.398 0.52 125–127 11.2 ± 0.6
7 3-OH –COC6H5 409.442 0.50 230–231.5 8.5 ± 0.8
8 3-OH –COCH2CH2CH3 375.425 0.60 255–255.3 7.7 ± 0.5
9 4-OH –COCH3 347.371 0.56 124–125 13.6 ± 0.4
10 4-OH –COCH2CH3 361.398 0.80 135 12.8 ± 0.9
11 4-OH –COC6H5 409.442 0.48 232–233 11.1 ± 0.7
12 4-OH –COCH2CH2CH3 375.425 0.30 251–252 10.3 ± 0.7
13 3, 4-di OH –COCH3 363.370 0.75 180 11.8 ± 0.6
14 3, 4-di OH –COCH2CH3 377.397 0.40 200 10.1 ± 0.5
15 3, 4-di OH –COC6H5 425.441 0.65 240–242 8.2 ± 0.7
16 3, 4-di OH –COCH2CH2CH3 391.424 0.75 266 7.3 ± 0.3
Pacc 7.3 ± 0.7
  1. aMobile phase: dichloromethane: methanol (19:1)
  2. bMean ± S.D. (n = 3)
  3. cPac—Paclitaxel