C. no. | R1, R2 | Y | Mol. wt | Rf valuea | M. Pt. | IC50 (µM)b |
---|---|---|---|---|---|---|
1 | H, H | –COC6H5 | 393.443 | 0.57 | 210 | 13.1 ± 0.2 |
2 | H, H | –COCH2CH2CH3 | 359.426 | 0.51 | 121–123 | 12.5 ± 0.9 |
3 | H, H | –COCH3 | 331.372 | 0.46 | 164 | 17.8 ± 0.5 |
4 | H, H | –COCH2CH3 | 345.399 | 0.55 | 190 | 13.5 ± 0.7 |
5 | 3-OH | –COCH3 | 347.371 | 0.47 | 123 | 13.9 ± 0.6 |
6 | 3-OH | –COCH2CH3 | 361.398 | 0.52 | 125–127 | 11.2 ± 0.6 |
7 | 3-OH | –COC6H5 | 409.442 | 0.50 | 230–231.5 | 8.5 ± 0.8 |
8 | 3-OH | –COCH2CH2CH3 | 375.425 | 0.60 | 255–255.3 | 7.7 ± 0.5 |
9 | 4-OH | –COCH3 | 347.371 | 0.56 | 124–125 | 13.6 ± 0.4 |
10 | 4-OH | –COCH2CH3 | 361.398 | 0.80 | 135 | 12.8 ± 0.9 |
11 | 4-OH | –COC6H5 | 409.442 | 0.48 | 232–233 | 11.1 ± 0.7 |
12 | 4-OH | –COCH2CH2CH3 | 375.425 | 0.30 | 251–252 | 10.3 ± 0.7 |
13 | 3, 4-di OH | –COCH3 | 363.370 | 0.75 | 180 | 11.8 ± 0.6 |
14 | 3, 4-di OH | –COCH2CH3 | 377.397 | 0.40 | 200 | 10.1 ± 0.5 |
15 | 3, 4-di OH | –COC6H5 | 425.441 | 0.65 | 240–242 | 8.2 ± 0.7 |
16 | 3, 4-di OH | –COCH2CH2CH3 | 391.424 | 0.75 | 266 | 7.3 ± 0.3 |
Pacc | – | – | – | – | – | 7.3 ± 0.7 |