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Table 52 Topoisomerase II inhibitory activity against filarial parasite Setaria cervi

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds % Inhibition at different concentrations
40 µg/ml 20 µg/ml 10 µg/ml 5 µg/ml
h9 60 60
h10 60 60
h11 80 80 80
h12 80 80 80 60
h13 80 80 80 60
h14 80 80 80 25
h15 70 70 70 40
DEC (antifilarial) 45 10
Novobiocin (topo II inhibitor) 80 20 10
Nalidixic acid (topo II inhibitor) 80 40 20