Table 52 Topoisomerase II inhibitory activity against filarial parasite Setaria cervi
From: Therapeutic potential of heterocyclic pyrimidine scaffolds
Compounds | % Inhibition at different concentrations | |||
|---|---|---|---|---|
40 µg/ml | 20 µg/ml | 10 µg/ml | 5 µg/ml | |
h9 | 60 | 60 | – | – |
h10 | 60 | 60 | – | – |
h11 | 80 | 80 | 80 | – |
h12 | 80 | 80 | 80 | 60 |
h13 | 80 | 80 | 80 | 60 |
h14 | 80 | 80 | 80 | 25 |
h15 | 70 | 70 | 70 | 40 |
DEC (antifilarial) | 45 | 10 | – | – |
Novobiocin (topo II inhibitor) | 80 | 20 | 10 | – |
Nalidixic acid (topo II inhibitor) | 80 | 40 | 20 | – |