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Table 40 Anti-inflammatory activity of pyrimidine derivatives

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Comp. Percent inhibition ± SEM at various time intervals
0.5 h 1.0 h 2.0 h 3.0 h 4.0 h 6.0 h
e8 15.22 ± 0.68* 50.45 ± 1.23* 87.23 ± 2.61* 62.51 ± 2.33* 56.94 ± 1.79 48.39 ± 2.65
e9 18.26 ± 0.68* 49.35 ± 1.41* 86.99 ± 2.62* 62.13 ± 2.25* 53.32 ± 2.01 42.11 ± 2.75
Ibuprofen 20.26 ± 0.90* 53.95 ± 0.97* 97.09 ± 2.86* 79.97 ± 2.38* 67.93 ± 2.22* 58.02 ± 1.87*
  1. All values are represented as mean ± SEM (n = 6). *P < 0.01 compared to saline control group. One-way ANOVA, Dunnett’s t test. Dosage: Ibuprofen-10 mg/kg and test compounds-10 mg/kg body weight by orally