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Table 40 Anti-inflammatory activity of pyrimidine derivatives

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Comp.

Percent inhibition ± SEM at various time intervals

0.5 h

1.0 h

2.0 h

3.0 h

4.0 h

6.0 h

e8

15.22 ± 0.68*

50.45 ± 1.23*

87.23 ± 2.61*

62.51 ± 2.33*

56.94 ± 1.79

48.39 ± 2.65

e9

18.26 ± 0.68*

49.35 ± 1.41*

86.99 ± 2.62*

62.13 ± 2.25*

53.32 ± 2.01

42.11 ± 2.75

Ibuprofen

20.26 ± 0.90*

53.95 ± 0.97*

97.09 ± 2.86*

79.97 ± 2.38*

67.93 ± 2.22*

58.02 ± 1.87*

  1. All values are represented as mean ± SEM (n = 6). *P < 0.01 compared to saline control group. One-way ANOVA, Dunnett’s t test. Dosage: Ibuprofen-10 mg/kg and test compounds-10 mg/kg body weight by orally
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BMC Chemistry

ISSN: 2661-801X

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