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Table 39 Anti-inflammatory activity of the fused thienopyrimidines in formalin-induced rat paw edema bioassay (acute inflammatory model)

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds

Volume of edema (ml)a

ED50 (mg/kg)

0

1 h

2 h

4 h

e5

0.31 ± 0.01

0.44 ± 0.02b (38)c

0.49 ± 0.01b (43)

0.52 ± 0.02b (52)

23.45d

e6

0.35 ± 0.02

0.46 ± 0.01b (47)

0.50 ± 0.01b (53)

0.54 ± 0.02b (56)

28.15

e7

0.33 ± 0.02

0.46 ± 0.01b (42)

0.53 ± 0.01b (37)

0.59 ± 0.02b (40)

26.12

Control

0.32 ± 0.01

0.55 ± 0.01

0.64 ± 0.02

0.76 ± 0.01

–

Diclofenac

0.32 ± 0.02

0.45 ± 0.01b (38)

0.50 ± 0.02b (43)

0.53 ± 0.02b (52)

25.13

  1. aValues are expressed as mean ± SE (number of animals N = 5 rats)
  2. bSignificantly different compared to corresponding control P ≤ 0.05
  3. cBetween parentheses (percentage anti-inflammatory activity %)
  4. dED50 is the effective dose calculated after 2 h