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Table 39 Anti-inflammatory activity of the fused thienopyrimidines in formalin-induced rat paw edema bioassay (acute inflammatory model)

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds Volume of edema (ml)a ED50 (mg/kg)
0 1 h 2 h 4 h
e5 0.31 ± 0.01 0.44 ± 0.02b (38)c 0.49 ± 0.01b (43) 0.52 ± 0.02b (52) 23.45d
e6 0.35 ± 0.02 0.46 ± 0.01b (47) 0.50 ± 0.01b (53) 0.54 ± 0.02b (56) 28.15
e7 0.33 ± 0.02 0.46 ± 0.01b (42) 0.53 ± 0.01b (37) 0.59 ± 0.02b (40) 26.12
Control 0.32 ± 0.01 0.55 ± 0.01 0.64 ± 0.02 0.76 ± 0.01
Diclofenac 0.32 ± 0.02 0.45 ± 0.01b (38) 0.50 ± 0.02b (43) 0.53 ± 0.02b (52) 25.13
  1. aValues are expressed as mean ± SE (number of animals N = 5 rats)
  2. bSignificantly different compared to corresponding control P ≤ 0.05
  3. cBetween parentheses (percentage anti-inflammatory activity %)
  4. dED50 is the effective dose calculated after 2 h