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Table 36 In vitro antimalarial activity of N-aryl and heteroaryl sulfonamide derivatives

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds

P. falciparum (IC50 in µM (µg/ml))

P. falciparum (D6)

P. falciparum (W2)

IC50

SI

IC50

SI

d11

4.86 (2.3)

> 10.8

6.39 (3.02)

> 8.2

d12

2.56 (1.38)

> 18

3.41 (1.84)

> 13.5

Artemisinin

< 0.09 (< 0.03)

–

< 0.09 (< 0.03)

–

Chloroquine

< 0.08 (< 0.03)

–

0.72 (0.23)

–

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BMC Chemistry

ISSN: 2661-801X

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