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Table 36 In vitro antimalarial activity of N-aryl and heteroaryl sulfonamide derivatives

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds P. falciparum (IC50 in µM (µg/ml))
P. falciparum (D6) P. falciparum (W2)
IC50 SI IC50 SI
d11 4.86 (2.3) > 10.8 6.39 (3.02) > 8.2
d12 2.56 (1.38) > 18 3.41 (1.84) > 13.5
Artemisinin < 0.09 (< 0.03) < 0.09 (< 0.03)
Chloroquine < 0.08 (< 0.03) 0.72 (0.23)