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Table 30 Antiviral activity results of test compounds (c2c4) in cell culture

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds EC 50 a (µmol/ml) CC 50 b
HIV (IIIB) HIV-2 (ROD) MSV (µmol/ml) (CEM)
c2 0.011 0.0045 0.0095 ≥ 0.3
c3 0.0045 0.0027 0.021 ≥ 0.3
c4 0.080 0.050 ≥ 0.2
Adefovir 0.0033 0.0066 0.0022 0.056
Tenofovir 0.0012 0.0014 0.0046 0.14
  1. a50% effective concentration; b 50% cytostatic concentration