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Table 30 Antiviral activity results of test compounds (c2–c4) in cell culture

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds

EC a50 (µmol/ml)

CC b50

HIV (IIIB)

HIV-2 (ROD)

MSV

(µmol/ml) (CEM)

c2

0.011

0.0045

0.0095

≥ 0.3

c3

0.0045

0.0027

0.021

≥ 0.3

c4

0.080

0.050

–

≥ 0.2

Adefovir

0.0033

0.0066

0.0022

0.056

Tenofovir

0.0012

0.0014

0.0046

0.14

  1. a50% effective concentration; b 50% cytostatic concentration