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Table 27 Cytotoxicity of compound b31

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compound

IC50 (µmol/l) ± SD

H460

HT-29

MKN-45

MDA-MB-231

b31

0.057 ± 0.011

0.039 ± 0.008

0.25 ± 0.019

0.23 ± 0.020

GDC-0941

0.87 ± 0.20

0.86 ± 0.081

0.60 ± 0.12

0.28 ± 0.06

Sorafenib

2.19 ± 0.11

3.61 ± 0.36

2.32 ± 0.35

0.94 ± 0.13