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Table 27 Cytotoxicity of compound b31

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compound IC50 (µmol/l) ± SD
H460 HT-29 MKN-45 MDA-MB-231
b31 0.057 ± 0.011 0.039 ± 0.008 0.25 ± 0.019 0.23 ± 0.020
GDC-0941 0.87 ± 0.20 0.86 ± 0.081 0.60 ± 0.12 0.28 ± 0.06
Sorafenib 2.19 ± 0.11 3.61 ± 0.36 2.32 ± 0.35 0.94 ± 0.13