Table 26 Anticancer activity of triazole/isoxazole functionalized pyridopyrimidine derivatives
From: Therapeutic potential of heterocyclic pyrimidine scaffolds
Compounds | GI50 values in µM | |||
|---|---|---|---|---|
MDA MB-231 | PANC1 | A549 | HeLa | |
b29 | 2.21 ± 0.08 | 0.02 ± 0.01 | 0.86 ± 0.03 | 0.81 ± 0.02 |
b30 | 2.83 ± 0.05 | 0.73 ± 0.01 | 0.03 ± 0.01 | 0.93 ± 0.03 |
Nocodazole | 0.042 ± 0.001 | 0.029 ± 0.003 | 0.08 ± 0.001 | 0.063 ± 0.002 |