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Table 26 Anticancer activity of triazole/isoxazole functionalized pyridopyrimidine derivatives

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

Compounds GI50 values in µM
MDA MB-231 PANC1 A549 HeLa
b29 2.21 ± 0.08 0.02 ± 0.01 0.86 ± 0.03 0.81 ± 0.02
b30 2.83 ± 0.05 0.73 ± 0.01 0.03 ± 0.01 0.93 ± 0.03
Nocodazole 0.042 ± 0.001 0.029 ± 0.003 0.08 ± 0.001 0.063 ± 0.002