Table 21 In vitro cytotoxicity of pyrido[2,3-d]pyrimidine derivatives against U937, THP-1 and Colo205 cancer cell lines
From: Therapeutic potential of heterocyclic pyrimidine scaffolds
Compounds | IC50 (µg/ml) | ||
|---|---|---|---|
U937 | THP-1 | Colo205 | |
b17 | 8.16 ± 0.68 | 16.91 ± 1.42 | 19.25 ± 1.46 |
b18 | 6.20 ± 0.68 | 11.27 ± 1.67 | 15.01 ± 1.54 |
Etoposide (positive control) | 17.94 ± 1.19 | 2.16 ± 0.15 | 7.24 ± 1.26 |