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Table 10 Pharmacological evaluation (MIC = µg/ml) of the 2-substituted 5-(1,2-diarylethyl)-4,6-dichloropyrimidines

From: Therapeutic potential of heterocyclic pyrimidine scaffolds

  a18 a19 a20 a21
Axillary bacterial flora
 Staphylococcus xylosus 20 100 100 100
 Staphylococcus epidermidis 100 100 100 75
 Staphylococcus haemolyticus 100 100 100 50
 Corynebacterium xerosis 20 30 30 30
 Micrococcus luteus 20 100 100 100
 Arcanobacterium haemolyticum 10 10 10 10
Foot bacterial flora
 Staphylococcus epidermidis > 100 100 100 75
 Staphylococcus hominis 100 100 100 75
 Staphylococcus cohnii 100 100 100 75
 Corynebacterium sp. g C 100 100 100 75
 Corynebacterium sp. g B 30 100 100 50
 Corynebacterium sp. g D2 30 100 50 50
 Micrococcus luteus 20 100 100 75
 Micrococcus sedentarius 30 100 100 75
 Acinetobacter sp. > 1000 > 500 50 30
 Moraxella sp. 300 30 100 50
 Alcaligenes sp. 1000 > 500 > 500 > 500