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Table 1 IC50 values of curcuminoids against HeLa, K562, MCF-7 and MBA-MB-231

From: Design, synthesis and cytotoxic effects of curcuminoids on HeLa, K562, MCF-7 and MDA-MB-231 cancer cell lines

Compounds

HeLa

K562

MCF-7

MDA-MB-231

IC50 (µg/mL)

1

9.21 ± 1.20

16.04 ± 1.30

3.46 ± 1.22

3.01 ± 0.60

2

38.03 ± 3.10

30.12 ± 3.30

42.00 ± 4.20

65.00 ± 4.10

3

12.50 ± 1.30

22.50 ± 3.20

8.50 ± 1.50

9.50 ± 1.40

4

11.04 ± 2.80

6.50 ± 01.80

8.70 ± 3.10

2.30 ± 1.60

5

> 30

17.50 ± 0.50

6.03 ± 1.70

3.03 ± 1.00

6

15.07 ± 1.60

20.04 ± 1.10

> 30

> 30

7

12.00 ± 1.60

22.50 ± 1.10

10.50 ± 2.10

7.401 ± 1.10

8

> 30

> 30

6.50 ± 2.70

3.02 ± 1.10

9

11.01 ± 2.10

55.02 ± 3.40

10.50 ± 1.80

6.30 ± 1.30

10

> 30

> 30

14.02 ± 1.80

11.90 ± 3.10

11

11.31 ± 1.33

15.03 ± 1.90

4.50 ± 1.20

2.07 ± 1.75

12

12.01 ± 1.10

32.50 ± 2.10

20.50 ± 2.50

11.00 ± 2.10

13

15.20 ± 1.20

> 30

10.00 ± 2.10

9.50 ± 1.10

14

14.03 ± 1.40

> 30

3.02 ± 1.20

1.52 ± 0.60

15

> 30

15.01 ± 1.30

7.50 ± 1.10

9.20 ± 0.80

16

11.00 ± 1.20

12.50 ± 0.95

25.00 ± 3.20

14.21 ± 2.10

17

6.15 ± 1.20

> 30

2.50 ± 1.10

3.10 ± 1.06

18

> 30

> 30

> 30

18.13 ± 6.10

19

> 30

> 30

> 30

> 30

20

> 30

> 30

> 30

> 30

21

> 30

> 30

> 30

27.50 ± 4.40

22

9.00 ± 1.60

> 30

12.50 ± 2.10

6.40 ± 1.10

23

> 30

> 30

> 30

> 30

24

> 30

> 30

> 30

> 30

Curcumin

> 30

> 30

22.50 ± 5.50

26.50 ± 1.40

Doxorubicin

4.01 ± 1.20

1.23 ± 1.10

2.50 ± 1.10

0.60 ± 1.10

  1. Data are expressed in terms of ± SE of three independent experiments